cAMPS-Sp, triethylammonium salt

Name: cAMPS-Sp, triethylammonium salt
Brand: Tocris Bioscience
SKU: 1333

Tocris Bioscience, part of Bio-Techne | Catalog # 1333

Citations (4)

COA / SDS

Cell-permeable cAMP analog

Key Product Details

Description:	Cell-permeable cAMP analog
Chemical Name:	(S)-Adenosine, cyclic 3',5'-(hydrogenphosphorothioate) triethylammonium
Purity:	≥98% (HPLC)
Molecular Weight:	446.46

View Full Technical Details for cAMPS-Sp, triethylammonium salt

Technical Data
Citations

Biological Activity for cAMPS-Sp, triethylammonium salt

cAMPS-Sp, triethylammonium salt is a cell-permeable cAMP analog that activates cAMP receptor proteins such as PKA and cAMP-regulated guanine nucleotide exchange factor.

R-enantiomer also available.

Technical Data for cAMPS-Sp, triethylammonium salt

M. Wt	446.46
Formula	C₁₀H₁₂N₅O₅PS.C₆H₁₅N
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	93602-66-5
PubChem ID	57369926
InChi Key	OXIPZMKSNMRTIV-UHFFFAOYSA-N
Smiles	[H][C@@]([C@@](O[C@@H](N3C=NC4=C3N=CN=C4N)[C@@H]2O)([H])CO1)2O[P@]1([S-])=O.CC[NH+](CC)CC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for cAMPS-Sp, triethylammonium salt

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	44.65	100

Preparing Stock Solutions for cAMPS-Sp, triethylammonium salt

The following data is based on the product molecular weight 446.46.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.24 mL	11.20 mL	22.40 mL
5 mM	0.45 mL	2.24 mL	4.48 mL
10 mM	0.22 mL	1.12 mL	2.24 mL
50 mM	0.04 mL	0.22 mL	0.45 mL

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References for cAMPS-Sp, triethylammonium salt

References are publications that support the biological activity of the product.

O'Brian A kinetic study of interactions of (R_p)- and (S_p)-adenosine cyclic 3',5'-phosphorothioates with type II bovine cardiac muscle adenosine cyclic 3',5'-phosphate dependent protein kinase. Biochemistry 1982 PMID: 6289880
Kawasaki A family of cAMP-binding proteins that directly activate Rap1. Science 1998 PMID: 9856955
Lin Ethanol inhibition of NMDA-induced responses and actute tolerance to the inhibition in rat rostral ventrolateral medulla in vivo: Involvement of cAMP-dependent protein kinases. Neuropharmacology 2006 PMID: 16806304
Dostmann Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3',5'-cyclic phosphorothioates. J.Biol.Chem. 1990 PMID: 2162349