Ceapin A7

Name: Ceapin A7
Brand: Tocris Bioscience
SKU: 6955

Tocris Bioscience, part of Bio-Techne | Catalog # 6955

Citations (1)

COA / SDS

Selective inhibitor of ATF6α; sensitizes cells to ER stress

Key Product Details

Description:	Selective inhibitor of ATF6α; sensitizes cells to ER stress
Chemical Name:	N-[1-[[2,4-bis(Trifluoromethyl)phenyl]methyl]-1H-pyrazol-4-yl]-5-(2-furanyl)-3-isoxazolecarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	470.33

View Full Technical Details for Ceapin A7

Technical Data
Citations

Biological Activity for Ceapin A7

Ceapin A7 is a selective inhibitor of ATF6α (IC₅₀=0.59 μM). The compound selectively inhibits ATF6α over ATF6β and other branches of the unfolded protein response (UPR). Ceapin A7 inhibits ER stress-induced upregulation of BiP in vitro. Ceapin A7 inhibits cleavage and functional activation of endogenous ATF6 in response to ER stress in vitro.

Technical Data for Ceapin A7

M. Wt	470.33
Formula	C₂₀H₁₂F₆N₄O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2323027-38-7
PubChem ID	154730128
InChi Key	UJTDYOXTXGBHEG-UHFFFAOYSA-N
Smiles	FC(F)(C1=CC(C(F)(F)F)=C(C=C1)CN2C=C(C=N2)NC(C3=NOC(C4=CC=CO4)=C3)=O)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Ceapin A7

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	47.03	100
	ethanol	4.7	10

Preparing Stock Solutions for Ceapin A7

The following data is based on the product molecular weight 470.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.13 mL	10.63 mL	21.26 mL
5 mM	0.43 mL	2.13 mL	4.25 mL
10 mM	0.21 mL	1.06 mL	2.13 mL
50 mM	0.04 mL	0.21 mL	0.43 mL

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References for Ceapin A7

References are publications that support the biological activity of the product.

Gallagher and Walter Ceapins inhibit ATF6a signaling by selectively preventing transport of ATF6a to the Golgi apparatus during ER stress. eLife 2016 PMID: 27435962
Gallagher Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6a branch. eLife 2016 PMID: 27435960