Ceefourin 1

Name: Ceefourin 1
Brand: Tocris Bioscience
SKU: 5867

Tocris Bioscience, part of Bio-Techne | Catalog # 5867

Citations (4)

COA / SDS

Selective MRP4 inhibitor

Key Product Details

Description:	Selective MRP4 inhibitor
Chemical Name:	5-[(2-Benzothiazolylthio)methyl]-2,4-dihydro-4-methyl-3H-1,2,4-triazole-3-thione
Purity:	≥98% (HPLC)
Molecular Weight:	294.42

View Full Technical Details for Ceefourin 1

Technical Data
Citations

Biological Activity for Ceefourin 1

Ceefourin 1 is a selective MRP (multidrug resistance-associated protein) 4 inhibitor (IC₅₀ = 2.6 μM). Selective for MRP4 over P-gp, MRP1 and ABCG2. Sensitizes MRP4 over-expressing cells to SN 38 (Cat. No. 2684). Ceefourin 1 inhibits cAMP efflux from acute myeloid leukemia cells (AML) and promotes apoptosis in combination with Histamine (Cat. No. 3545).

Technical Data for Ceefourin 1

M. Wt	294.42
Formula	C₁₁H₁₀N₄S₃
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	315702-40-0
PubChem ID	704306
InChi Key	KVNBVHCJAUXKPJ-UHFFFAOYSA-N
Smiles	CN1C(NN=C1CSC2=NC3=CC=CC=C3S2)=S

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Ceefourin 1

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	29.44	100

Preparing Stock Solutions for Ceefourin 1

The following data is based on the product molecular weight 294.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.40 mL	16.98 mL	33.97 mL
5 mM	0.68 mL	3.40 mL	6.79 mL
10 mM	0.34 mL	1.70 mL	3.40 mL
50 mM	0.07 mL	0.34 mL	0.68 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for Ceefourin 1

References are publications that support the biological activity of the product.

Sahores Ceefourin-1, a MRP4/ABCC4 inhibitor, induces apoptosis in AML cells enhanced by histamine. Biochim.Biophys.Acta 2023 PMID: 36773726
Cheung High-throughput screening identifies Ceefourin 1 and Ceefourin 2 as highly selective inhibitors of multidrug resistance protein 4 (MRP4). Biochem.Pharmacol. 2014 PMID: 24973542