Cerestat

Name: Cerestat
Brand: Tocris Bioscience
SKU: 4492

Tocris Bioscience, part of Bio-Techne | Catalog # 4492

COA / SDS

Potent and noncompetitive NMDA antagonist

Key Product Details

Description:	Potent and noncompetitive NMDA antagonist
Alternative Names:	CNS 1102
Chemical Name:	N-(3-Ethylphenyl)-N-methyl-N'-1-naphthalenylguanidine hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	339.86

View Full Technical Details for Cerestat

Technical Data
Citations

Biological Activity for Cerestat

Cerestat is a potent and noncompetitive NMDA receptor antagonist (IC₅₀ = 36 nM). Exhibits >70-fold selectivity for NMDA receptor over σ receptor. Neuroprotective in a rat model of focal ischemia.

Technical Data for Cerestat

M. Wt	339.86
Formula	C₂₀H₂₁N₃.HCl
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	137160-11-3
PubChem ID	60839
InChi Key	CKAKVKWRMCAYJD-UHFFFAOYSA-N
Smiles	N=C(N(C)C3=CC=CC(CC)=C3)NC1=C2C(C=CC=C2)=CC=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Cerestat

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	16.99	50
	DMSO	33.99	100

Preparing Stock Solutions for Cerestat

The following data is based on the product molecular weight 339.86.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.94 mL	14.71 mL	29.42 mL
5 mM	0.59 mL	2.94 mL	5.88 mL
10 mM	0.29 mL	1.47 mL	2.94 mL
50 mM	0.06 mL	0.29 mL	0.59 mL

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Reconstitution Calculator

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References for Cerestat

References are publications that support the biological activity of the product.

Schäbitz The N-MthD.-aspartate antagonist CNS 1102 protects cerebral gray and white matter from ischemic injury following temporary focal ischemia in rats. Stroke 2000 PMID: 10884477
Reddy Synthesis and structure-activity studies of N,N'-diarylguanidine derivatives. N-(1-naphthyl)-N'-(3-ethylphenyl)-N'-methylguanidine: a new, selective noncompetitive NMDA receptor antagonist. J.Med.Chem. 1994 PMID: 8295213