CGP 71683 hydrochloride

Name: CGP 71683 hydrochloride
Brand: Tocris Bioscience
SKU: 2199

Tocris Bioscience, part of Bio-Techne | Catalog # 2199

Citations (8)

COA / SDS

Highly selective and potent non-peptide NPY Y5 receptor antagonist

Key Product Details

Chemical Name:	N-[[trans-4-[[(4-Amino-2-quinazolinyl)amino]methyl]cyclohexyl]methyl]-1-naphthalenesulfonamide hydrochloride
Purity:	≥98%
Molecular Weight:	512.07 kDa

View Full Technical Details for CGP 71683 hydrochloride

Technical Data
Citations

Biological Activity for CGP 71683 hydrochloride

CGP 71683 hydrochloride is an extremely selective, non-peptide NPY Y₅ receptor antagonist. Displays > 1000-fold selectivity over Y₁, Y₂ and Y₄ receptors; IC₅₀ values are 1.4, 2765, 7187 and 5637 nM at cloned rat Y₅, Y₁, Y₂ and Y₄ receptors respectively. Potently inhibits NPY-induced food intake following i.p. administration in diabetic, free-feeding and fasted rats.

Technical Data for CGP 71683 hydrochloride

M. Wt	512.07 kDa
Formula	C₂₆H₂₉N₅O₂S.HCl
Storage	Store at +4°C
Purity	≥98%
CAS Number	192322-50-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CGP 71683 hydrochloride

Solubility

Soluble Soluble to 100 mM in DMSO

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References for CGP 71683 hydrochloride

References are publications that support the biological activity of the product.

Czarnecka M, Trinh E, Lu C, Kuan-Celarier A, Galli S, Hong S, Tilan J, Talisman N, Izycka-Swieszewska E, Tsuei J, Yang C, Martin S, Horton M, Christian D, Everhart L, Maheswaran I, Kitlinska J Neuropeptide Y receptor Y5 as an inducible pro-survival factor in neuroblastoma: implications for tumor chemoresistance. Oncogene, 2015;34(24):3131-43. 2015 PMID: 25132261
Reidelberger, Roger, Haver, Alvin, Chelikani, Prasanth Role of peptide YY(3-36) in the satiety produced by gastric delivery of macronutrients in rats. Am J Physiol Endocrinol Metab, 2013;304(9):E944-50. 2013 PMID: 23482449
Criscione et al. Food intake in free-feeding and energy-deprived lean rats is mediated by the neuropeptide Y₅ receptor. J.Clin.Invest., 1998;102:2136 PMID: 9854049
Dumont et al. Potent and selective tools to investigate neuropeptide Y receptors in the central and peripheral nervous systems: BIB03304 (Y1) and CGP71683A (Y5). Can.J.Physiol.Pharmacol., 2000;78:116 PMID: 10737674
Lecklin et al. Receptor subtypes Y₁ and Y₅ mediate neuropeptide Y induced feeding in the guinea-pig. Br.J.Pharmacol., 2002;135:2029 PMID: 11959807