CGS 21680 hydrochloride

Name: CGS 21680 hydrochloride
Brand: Tocris Bioscience
SKU: 1063
Rating: 5 (2 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1063

(2)

Citations (79)

COA / SDS

A2A agonist

Key Product Details

Description:	A_2A agonist
Chemical Name:	4-[2-[[6-Amino-9-(N-ethyl-β-D-ribofuranuronamidosyl)-9H-purin-2-yl]amino]ethyl]benzenepropanoic acid hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	535.99

View Full Technical Details for CGS 21680 hydrochloride

Technical Data
Citations / Reviews (2)

Biological Activity for CGS 21680 hydrochloride

CGS 21680 hydrochloride is a potent A_2A adenosine receptor agonist (K_i = 27 nM, EC₅₀ = 1.48-180 nM). CGS 21680 reduces venous resistance, increases heart rate and cardiac output in vivo. In an animal model of Huntington's disease, CGS21680 slows motor deterioration, prevents reduction in brain weight and reduces the size of mutant huntingtin aggregates and intranuclear inclusions. CGS21680 increases proliferation of neural progenitor cells, promotes survival of motoneurons and activates TrkB receptors. Also has anti-inflammatory effects in animal models of lung injury and reduces neurotoxicity induced by Kainate (Cat. No. 7065).

Compound Libraries for CGS 21680 hydrochloride

CGS 21680 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CGS 21680 hydrochloride

M. Wt	535.99
Formula	C₂₃H₂₉N₇O₆.HCl
Storage	Desiccate at -20°C
Purity	≥98% (HPLC)
CAS Number	124431-80-7
PubChem ID	10256643
InChi Key	QPHVMNOEKKJYJO-MJWSIIAUSA-N
Smiles	NC1=NC(NCCC4=CC=C(CCC(O)=O)C=C4)=NC2=C1N=CN2[C@@H]3O[C@H]([C@](NCC)=O)[C@@H](O)[C@H]3O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CGS 21680 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	53.6	100

Preparing Stock Solutions for CGS 21680 hydrochloride

The following data is based on the product molecular weight 535.99.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.87 mL	9.33 mL	18.66 mL
5 mM	0.37 mL	1.87 mL	3.73 mL
10 mM	0.19 mL	0.93 mL	1.87 mL
50 mM	0.04 mL	0.19 mL	0.37 mL

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References for CGS 21680 hydrochloride

References are publications that support the biological activity of the product.

Komaki Trk and cAMP-dependent survival activity of adenosine A(2A) agonist CGS21680 on rat motoneurons in culture. Neurosci.Lett. 2012 PMID: 22691937
Rebola Different roles of adenosine A₁, A_2A and A₃ receptors in controlling kainate-induced toxicity in cortical cultured neurons. Neurochem.Int. 2005 PMID: 16011860
Shryock A_2A-adenosine receptor reserve for coronary vasodilation. Circulation 1998 PMID: 9715864
Wiese Adenosine receptor A_2A-R contributes to motoneuron survival by transactivating the tyrosine kinase receptor TrkB Proc.Natl.Acad.Sci.U.S.A. 2007 PMID: 17940030
Chou CGS21680 attenuates symptoms of Huntington's disease in a transgenic mouse model. J.Neurochem. 2005 PMID: 15816854
Phillis The selective adenosine A₂ receptor agonist, CGS 21680, is a potent depressant of cerebral cortical neuronal activity. Brain Res. 1990 PMID: 2322828
Nekooeian and Tabrizchi Effects of CGS 21680, a selective A_2A adenosine receptor agonist, on cardiac output and vascular resistance in acute heart failure in the anaesthetized rat. Br.J.Pharmacol. 1998 PMID: 9605574
Klot Adenosine receptors and their ligands. Naunyn Schmiedebergs Arch.Pharmacol. 2000 PMID: 11111832