CP 154526

Name: CP 154526
Brand: Tocris Bioscience
SKU: 2779

Tocris Bioscience, part of Bio-Techne | Catalog # 2779

Citations (17)

COA / SDS

Selective, non-peptide CRF1 antagonist

Key Product Details

Chemical Name:	N-Butyl-N-ethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine hydrochloride
Purity:	≥99%
Molecular Weight:	400.99 kDa

View Full Technical Details for CP 154526

Technical Data
Citations

Biological Activity for CP 154526

CP 154526 is a selective, non-peptide CRF₁ receptor antagonist (K_i values are 2.7 and > 10000 nM for CRF₁ and CRF₂ receptors respectively). Blocks CRF-induced adenylate cyclase activation (K_i = 3.7 nM) and attenuates activation of the HPA axis by CRF. Displays anxiolytic-like activity in the rat elevated plus-maze test; brain penetrant.

Technical Data for CP 154526

M. Wt	400.99 kDa
Formula	C₂₃H₃₂N₄.HCl
Storage	Desiccate at +4°C
Purity	≥99%
CAS Number	257639-98-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CP 154526

Solubility

Soluble Soluble to 50 mM in DMSO and to 50 mM in ethanol

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References for CP 154526

References are publications that support the biological activity of the product.

Hodgson et al. Comparison of the V1b antagonist, SSR149415, and the CRF1 antagonist, CP-154,526, in rodent models of anxiety and depression. Pharmacol.Biochem.Behav., 2007;86:431 PMID: 17291571
Lundkist et al. A non peptidic cortico. releasing factor receptor antagonist attenuates fever and exhibits anxiolytic activity. Eur.J.Pharmacol., 1996;309:195 PMID: 8874139