CRF1 Receptor Antagonists: Small Molecules and Peptides
CRHR1, also known as CHR-R1 and Corticotropin Releasing Factor Receptor 1, CRF 1, is a member of the Class B G protein-coupled receptor family that mediates the action of hypothalamic and peripheral CRH. It is the key regulator of the stress response in the hypothalamic-pituitary adrenal axis and an important functional mediator of the endocrine, cardiovascular, gastrointestinal, and immune systems. The other major endogenous ligand for CRHR1 is Urocortin 1.
7 results for "CRF1 Receptor Antagonists Small Molecules and Peptides" in Products
7 results for "CRF1 Receptor Antagonists Small Molecules and Peptides" in Products
CRF1 Receptor Antagonists: Small Molecules and Peptides
CRHR1, also known as CHR-R1 and Corticotropin Releasing Factor Receptor 1, CRF 1, is a member of the Class B G protein-coupled receptor family that mediates the action of hypothalamic and peripheral CRH. It is the key regulator of the stress response in the hypothalamic-pituitary adrenal axis and an important functional mediator of the endocrine, cardiovascular, gastrointestinal, and immune systems. The other major endogenous ligand for CRHR1 is Urocortin 1.
Potent and selective CRF1 antagonist; anxiolytic
| Chemical Name: | 8-(6-Methoxy-2-methyl-3-pyridinyl)-2,7-dimethyl-N-[(1R)-1-methylpropyl]pyrazolo[1,5-a]-1,3,5-triazin-4-amine |
| Purity: | ≥98% (HPLC) |
Potent and selective CRF1 antagonist; binds at an allosteric site
| Chemical Name: | N-(1-Ethylpropyl)-3,6-dimethyl-2-(2,4,6-trimethylphenoxy)-4-pyridinamine hydrochloride |
| Purity: | ≥99% (HPLC) |
CRF1 antagonist
| Chemical Name: | N-Butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine hydrochloride |
| Purity: | ≥99% (HPLC) |
Selective non-peptide CRF1 antagonist
| Chemical Name: | 5-Chloro-N-(cyclopropylmethyl)-2-methyl-N-propyl-N'-(2,4,6-trichlorophenyl)-4,6-pyrimidinediamine hydrochloride |
| Purity: | ≥99% (HPLC) |
Potent and selective CRF1 antagonist
| Chemical Name: | (7S)-6-(Cyclopropylmethyl)-2-(2,4-dichlorophenyl)-7-ethyl-7,8-dihydro-4-methyl-6H-1,3,6,8a-tetraazaacenaphthylene hydrochloride |
| Purity: | ≥98% (HPLC) |
Selective, non-peptide CRF1 antagonist
| Chemical Name: | N-Butyl-N-ethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine hydrochloride |
| Purity: | ≥99% |
High affinity CRF1 antagonist; orally bioavailable
| Chemical Name: | 3-[6-(Dimethylamino)-4-methyl-3-pyridinyl]-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amine hydrochloride |
| Purity: | ≥98% |
