CTCE 9908

Name: CTCE 9908
Brand: Tocris Bioscience
SKU: 5130

Tocris Bioscience, part of Bio-Techne | Catalog # 5130

Citations (3)

COA / SDS

CXCR4 antagonist; antitumor

Key Product Details

Description:	CXCR4 antagonist; antitumor
Purity:	≥95% (HPLC)
Molecular Weight:	1927.27

View Full Technical Details for CTCE 9908

Technical Data
Citations

Biological Activity for CTCE 9908

CTCE 9908 is a CXCR4 antagonist; induces mitotic catastrophe in ovarian cancer cells. Displays additive cytotoxic effects when given with taxol (Cat. No. 1097). Enhances the efficacy of docetaxel (Cat. No. 4056) in a mouse model.

Technical Data for CTCE 9908

M. Wt	1927.27
Formula	C₈₆H₁₄₇N₂₇O₂₃
Single Letter Sequence	KGVSLSYRK KGVSLSYR* (Modifications: Amide bridge = 9-8*, Lys-9 = C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	1030384-98-5
PubChem ID	90489012
InChi Key	VUYRSKROGTWHDC-ICWZLGNASA-N
Smiles	[H]N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCCCCC(NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](N[H])CCCCN)C(C)C)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CTCE 9908

Solubility

Soluble to 2mg/ml in water

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References for CTCE 9908

References are publications that support the biological activity of the product.

Hassan CXCR4 peptide antagonist inhibits primary breast tumor growth, metastasis and enhances the efficacy of anti-VEGF treatment or doce. in a transgenic mouse model. Int.J.Cancer. 2011 PMID: 20830712
Faber The many facets of SDF-1alpha, CXCR4 agonists and antagonists on hematopoietic progenitor cells. J.Biomed.Biotechnol. 2007 PMID: 17541466
Kwong An antagonist of the chemokine receptor CXCR4 induces mitotic catastrophe in ovarian cancer cells. Mol.Cancer Ther. 2009 PMID: 19567818