CU-T12-9

Name: CU-T12-9
Brand: Tocris Bioscience
SKU: 5414

Tocris Bioscience, part of Bio-Techne | Catalog # 5414

(1)

Citations (4)

COA / SDS

Potent TLR1/2 agonist

Key Product Details

Chemical Name:	N-Methyl-4-nitro-2-(4-(4-trifluoromethyl)phenyl)-1H-imidazol-1-yl)aniline
Purity:	≥99%

View Full Technical Details for CU-T12-9

Technical Data
Citations / Reviews (1)

Biological Activity for CU-T12-9

CU-T12-9 is a potent TLR1/2 agonist (EC₅₀ = 52.9 nM). Activates the NF-κB pathway and upregulates proinflammatory cytokines in vitro. Also enhances TLR1 and TLR2 dimerization.

Technical Data for CU-T12-9

Formula	C₁₇H₁₃F₃N₄O₂
Storage	Store at +4°C
Purity	≥99%
CAS Number	1821387-73-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CU-T12-9

Solubility

Soluble Soluble to 100 mM in DMSO and to 20 mM in ethanol

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References for CU-T12-9

References are publications that support the biological activity of the product.

Cheng et al. Specific activation of the TLR1-TLR2 heterodimer by small-molecule agonists Sci.Adv., 2015;1:e1400139 PMID: 26101787
Cheng et al. Discovery of small molecule inhibitors of the TLR1-TLR2 complex. Angew.Chem.Int.Ed.Engl., 2013;51:12246 PMID: 22969053

CU-T12-9

Tocris Bioscience, part of Bio-Techne | Catalog # 5414

Key Product Details

Biological Activity for CU-T12-9

Technical Data for CU-T12-9

Solubility for CU-T12-9

Dilution Calculator

Reconstitution Calculator

References for CU-T12-9

Product Documents for CU-T12-9

COA

Certificate of Analysis

SDS

CONTACT INFORMATION

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