Toll-like Receptor Agonists Products
TLRs make up a family of pattern recognition receptors that play important roles in the innate immune response. Broad classes of pathogens (e.g. viruses, bacteria, and fungi) constitutively express a set of mutation-resistant molecules called pathogen-associated molecular patterns (PAMPs). These microbial molecular markers may be composed of proteins, carbohydrates, lipids, nucleic acids and/or combinations thereof. Individual TLRs recognize distinct pathogen-associated PAMPs, initiating signaling cascades that promote the immune response. Structurally, TLRs are type I transmembrane receptors that possess varying numbers of extracellular N-terminal leucine-rich repeat (LRR) motifs, followed by a cysteine-rich region, a TM domain, and an intracellular Toll/IL-1 R (TIR) motif. The TIR motif is common to the larger IL-1 R/TLR superfamily.
8 results for "Toll-like Receptor Agonists" in Products
8 results for "Toll-like Receptor Agonists" in Products
Toll-like Receptor Agonists Products
TLRs make up a family of pattern recognition receptors that play important roles in the innate immune response. Broad classes of pathogens (e.g. viruses, bacteria, and fungi) constitutively express a set of mutation-resistant molecules called pathogen-associated molecular patterns (PAMPs). These microbial molecular markers may be composed of proteins, carbohydrates, lipids, nucleic acids and/or combinations thereof. Individual TLRs recognize distinct pathogen-associated PAMPs, initiating signaling cascades that promote the immune response. Structurally, TLRs are type I transmembrane receptors that possess varying numbers of extracellular N-terminal leucine-rich repeat (LRR) motifs, followed by a cysteine-rich region, a TM domain, and an intracellular Toll/IL-1 R (TIR) motif. The TIR motif is common to the larger IL-1 R/TLR superfamily.
TLR3 agonist
| Chemical Name: | Polyinosinic-polycytidylic acid sodium salt |
TLR1/2 agonist; induces cytokine production
| Purity: | ≥95% (HPLC) |
Toll-like receptor 7 (TLR7) agonist
| Alternate Names: | R 848 |
| Chemical Name: | 1-[4-Amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol |
| Purity: | ≥98% (HPLC) |
Toll-like receptor 7 (TLR7) agonist
| Alternate Names: | R 837 |
| Chemical Name: | 1-(2-Methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine |
| Purity: | ≥99% (HPLC) |
Potent TLR7 agonist
| Chemical Name: | 6-Amino-2-(butylamino)-9-[[6-[2-(dimethylamino)ethoxy]-3-pyridinyl]methyl]-7,9-dihydro-8H-purin-8-one |
| Purity: | ≥98% (HPLC) |
Potent TLR7 agonist
| Chemical Name: | Methyl 3-[(6-amino-2-butoxy-7,8-dihydro-8-oxo-9H-purin-9-yl)methyl]benzeneacetate |
| Purity: | ≥98% (HPLC) |
Potent TLR1/2 agonist
| Chemical Name: | N-Methyl-4-nitro-2-(4-(4-trifluoromethyl)phenyl)-1H-imidazol-1-yl)aniline |
| Purity: | ≥99% (HPLC) |
TLR2/6 agonist; induces TNF-α production
| Purity: | ≥95% (HPLC) |
