Dapansutrile

Name: Dapansutrile
Brand: Tocris Bioscience
SKU: 6902

Tocris Bioscience, part of Bio-Techne | Catalog # 6902

Citations (4)

COA / SDS

NLRP3 inflammasome inhibitor; disrupts inflammasome formation

Key Product Details

Description:	NLRP3 inflammasome inhibitor; disrupts inflammasome formation
Chemical Name:	3-(Methylsulfonyl)propanenitrile
Purity:	≥98%
Molecular Weight:	133.17

View Full Technical Details for Dapansutrile

Technical Data
Citations

Biological Activity for Dapansutrile

Dapansutrile is a NLRP3 inflammasome inhibitor that disrupts inflammasome formation. Reduces LPS/ATP-induced IL-1β secretion in human and mouse macrophages in vitro, without affecting TNFα levels. Reduces LPS-induced inflammation in vivo. Also reduces joint swelling and markers of inflammation in synovial fluid in a mouse model of acute arthritis. Displays cardioprotective effects in a mouse model of cardiac ischemic reperfusion injury.

OLT1177® is a registered trademark of Olatec Therapeutics LLC in the United States and other countries.

Compound Libraries for Dapansutrile

Dapansutrile is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for Dapansutrile

M. Wt	133.17
Formula	C₄H₇NO₂S
Storage	Store at -20°C
Purity	≥98%
CAS Number	54863-37-5
PubChem ID	12714644
InChi Key	LQFRYKBDZNPJSW-UHFFFAOYSA-N
Smiles	C[S](=O)(=O)CCC#N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Dapansutrile

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	13.32	100
	ethanol	2.66	20

Preparing Stock Solutions for Dapansutrile

The following data is based on the product molecular weight 133.17.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	7.51 mL	37.55 mL	75.09 mL
5 mM	1.50 mL	7.51 mL	15.02 mL
10 mM	0.75 mL	3.75 mL	7.51 mL
50 mM	0.15 mL	0.75 mL	1.50 mL

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References for Dapansutrile

References are publications that support the biological activity of the product.

Marchetti NLRP3 inflammasome inhibitor OLT1177® suppresses joint inflammation in murine models of acute arthritis. Arthritis Res.Ther. 2018 PMID: 30075804
Toldo The NLRP3 inflammasome inhibitor, OLT1177® (Dapansutrile), reduces infarct size and preserves contractile function after ischemia reperfusion injury in the mouse. J.Cardiovasc.Pharmacol. 2019 PMID: 30747785
Marchetti OLT1177®, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation. Proc.Natl.Acad.Sci.USA. 2018 PMID: 29378952