Deschloroclozapine

Name: Deschloroclozapine
Brand: Tocris Bioscience
SKU: 7193

Tocris Bioscience, part of Bio-Techne | Catalog # 7193

Citations (9)

COA / SDS

High affinity and highly potent activator of hM3Dq and hM4Di DREADDs; rapidly blood brain barrier penetrant

Key Product Details

Description:	High affinity and highly potent activator of hM₃D_q and hM₄D_i DREADDs; rapidly blood brain barrier penetrant
Alternative Names:	DCZ
Chemical Name:	11-(4-Methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine
Purity:	≥98% (HPLC)
Molecular Weight:	292.39

View Full Technical Details for Deschloroclozapine

Technical Data
Citations

Biological Activity for Deschloroclozapine

Deschloroclozapine is a high affinity and highly potent activator of muscarinic DREADDs (K_i values are 6.3 nM for hM₃D_q and 4.2 nM for hM₄D_i, in vitro; EC₅₀ values are 0.13 nM for hM₃D_q and 0.081 nM for hM₄D_i, in vitro). Derivative of clozapine (Cat. No. 0444). Exhibits 100-fold greater affinity for hM₃D_q and hM₄D_i compared to clozapine N-oxide (CNO; Cat. No. 4936), and 50-fold greater affinity compared to DREADD agonist 21 (Cat. No. 5548). Displays low 'off-target' receptor binding (K_i >100 nM at majority of GPCRs, ion channels and transporters tested). Displays rapid (approx. 10 minutes after i.p injection) binding and activation of hM₃D_q and hM₄D_i in mice and non-human primates. Induces spatial memory deficits in non-human primates expressing hM₄D_i in the prefrontal cortex.

Technical Data for Deschloroclozapine

M. Wt	292.39
Formula	C₁₈H₂₀N₄
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	1977-07-7
PubChem ID	16103
InChi Key	VQHITFFJBFOMBG-UHFFFAOYSA-N
Smiles	CN1CCN(C2=NC3=C(C=CC=C3)NC4=CC=CC=C24)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Deschloroclozapine

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	29.24	100
	ethanol	29.24	100

Preparing Stock Solutions for Deschloroclozapine

The following data is based on the product molecular weight 292.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.42 mL	17.10 mL	34.20 mL
5 mM	0.68 mL	3.42 mL	6.84 mL
10 mM	0.34 mL	1.71 mL	3.42 mL
50 mM	0.07 mL	0.34 mL	0.68 mL

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References for Deschloroclozapine

References are publications that support the biological activity of the product.

Nagai Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys Nat.Neurosci. 2020 PMID: 32632286