Ec2la

Name: Ec2la
Brand: Tocris Bioscience
SKU: 6832

Tocris Bioscience, part of Bio-Techne | Catalog # 6832

COA / SDS

Positive allosteric modulator of CB2 receptors; active in vivo

Key Product Details

Description:	Positive allosteric modulator of CB₂ receptors; active in vivo
Chemical Name:	N-[5-Bromo-1-[(4-fluorophenyl)methyl]-1,2-dihydro-4-methyl-2-oxo-3-pyridinyl]cycloheptanecarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	435.33

View Full Technical Details for Ec2la

Technical Data
Citations

Biological Activity for Ec2la

Ec2la is a CB₂ receptor positive allosteric modulator. Enhances CP 55940 (Cat. No. 0949) and 2-Arachidonylglycerol (Cat. No. 1298)-stimulated binding of [³⁵S]GTPγS to CB₂ receptors, but has no effect in the absence of agonist. Exhibits antinociceptive effects in an animal model of neuropathic pain.

Compound Libraries for Ec2la

Ec2la is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Ec2la

M. Wt	435.33
Formula	C₂₁H₂₄BrFN₂O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2244579-87-9
PubChem ID	137553165
InChi Key	NSGDYZCDUPSTQT-UHFFFAOYSA-N
Smiles	CC1=C(C(N(C=C1Br)CC2=CC=C(C=C2)F)=O)NC(C3CCCCCC3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Ec2la

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	8.71	20

Preparing Stock Solutions for Ec2la

The following data is based on the product molecular weight 435.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	11.49 mL	57.43 mL	114.86 mL
1 mM	2.30 mL	11.49 mL	22.97 mL
2 mM	1.15 mL	5.74 mL	11.49 mL
10 mM	0.23 mL	1.15 mL	2.30 mL

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References for Ec2la

References are publications that support the biological activity of the product.

Gado Identification of the first synthetic allosteric modulator of the CB₂ receptors and evidence of its efficacy for neuropathic pain relief. J.Med.Chem. 2019 PMID: 29990428