G-15

Tocris Bioscience, part of Bio-Techne | Catalog # 3678

(1)

Citations (159)

COA / SDS

High affinity and selective GPER antagonist

Key Product Details

Description:	High affinity and selective GPER antagonist
Chemical Name:	(3aS,4R,9bR*)-4-(6-Bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta[c]quinoline
Purity:	≥99% (HPLC)
Molecular Weight:	370.24

View Full Technical Details for G-15

Technical Data
Citations / Reviews (1)

Biological Activity for G-15

G-15 is a high affinity and selective GPER receptor antagonist (K_i = 20 nM) that displays no affinity for ERα and ERβ at concentrations up to 10 μM. Inhibits agonist-induced calcium mobilization in vitro (EC₅₀ of ~185 nM) and antagonizes the antidepressive and renoprotective effects of estrogen in vivo.

Technical Data for G-15

M. Wt	370.24
Formula	C₁₉H₁₆BrNO₂
Storage	Store at -20°C
Purity	≥99% (HPLC)
CAS Number	1161002-05-6
PubChem ID	90488870
InChi Key	LBBDCJLRQXMUAE-FWHYVADDSA-N
Smiles	BrC1=CC4=C(OCO4)C=[C@@]1[C@@H]2NC(C=CC=C5)=C5[C@@]3([H])[C@@]([H])2CC=C3.BrC6=CC9=C(OCO9)C=[C@@]6[C@H]7NC(C=CC=C%10)=C%10[C@]8([H])[C@]([H])7CC=C8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for G-15

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	18.51	50

Preparing Stock Solutions for G-15

The following data is based on the product molecular weight 370.24.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.40 mL	27.01 mL	54.02 mL
2.5 mM	1.08 mL	5.40 mL	10.80 mL
5 mM	0.54 mL	2.70 mL	5.40 mL
25 mM	0.11 mL	0.54 mL	1.08 mL

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References for G-15

References are publications that support the biological activity of the product.

Hutchens Estrogen protects renal endothelial barrier function from ischemia-reperfusion in vitro and in vivo. Am.J.Physiol.Renal Physiol. 2012 PMID: 22622457
Yue Activation of G-protein-coupled receptor 30 protects neurons against excitotoxicity through inhibiting excessive autophagy induced by glutamate. ACS Chem.Neurosci. 2019 PMID: 31545891
Dennis In vivo effects of a GPR30 antagonist. Nat.Chem.Biol. 2009 PMID: 19430488