GSK 650394

Name: GSK 650394
Brand: Tocris Bioscience
SKU: 3572
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3572

(1)

Citations (72)

COA / SDS

Serum- and glucocorticoid-regulated kinase (SGK) inhibitor

Key Product Details

Description:	Serum- and glucocorticoid-regulated kinase (SGK) inhibitor
Chemical Name:	2-Cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl-benzoic acid
Purity:	≥97% (HPLC)
Molecular Weight:	382.45

View Full Technical Details for GSK 650394

Technical Data
Citations / Reviews (1)

Biological Activity for GSK 650394

GSK 650394 is a serum- and glucocorticoid-regulated kinase 1 (SGK1) inhibitor (IC₅₀ values are 62 and 103 nM for SGK1 and SGK2 respectively). Displays >30-fold selectivity over Akt and other related kinases. Inhibits androgen-stimulated growth of LNCaP cells, a human prostate carcinoma cell line (IC₅₀ ~ 1 μM).

Licensing Information

Sold with the permission of GlaxoSmithKline

Compound Libraries for GSK 650394

GSK 650394 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for GSK 650394

M. Wt	382.45
Formula	C₂₅H₂₂N₂O₂
Storage	Store at RT
Purity	≥97% (HPLC)
CAS Number	890842-28-1
PubChem ID	25022668
InChi Key	WVSBGSNVCDAMCF-UHFFFAOYSA-N
Smiles	O=C(C(C(C5CCCC5)=C4)=CC=C4C2=CNC1=NC=C(C3=CC=CC=C3)C=C12)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GSK 650394

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	38.24	100

Preparing Stock Solutions for GSK 650394

The following data is based on the product molecular weight 382.45.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.61 mL	13.07 mL	26.15 mL
5 mM	0.52 mL	2.61 mL	5.23 mL
10 mM	0.26 mL	1.31 mL	2.61 mL
50 mM	0.05 mL	0.26 mL	0.52 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for GSK 650394

References are publications that support the biological activity of the product.

Hall Serum and glucocorticoid-regulated kinase 1 (SGK1) activation in breast cancer: requirement for mTORC1 activity associates with ER-alpha expression. Breast Cancer Res.Treat 2012 PMID: 22842983
Sherk Development of a small-molecule serum- and glucocorticoid-regulated kinase-1 antagonist and its evaluation as a prostate cancer therapeutic. Cancer Res. 2008 PMID: 18794135