GSK J2

Name: GSK J2
Brand: Tocris Bioscience
SKU: 4688

Tocris Bioscience, part of Bio-Techne | Catalog # 4688

Citations (1)

COA / SDS

Inactive isomer of GSK J1 (Cat. No. 4593)

Key Product Details

Description:	Inactive isomer of GSK J1 (Cat. No. 4593)
Chemical Name:	N-[2-(3-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine ethyl ester
Purity:	≥98% (HPLC)
Molecular Weight:	389.45

View Full Technical Details for GSK J2

Technical Data
Citations

Biological Activity for GSK J2

GSK J2 is an inactive control of GSK J1 (IC₅₀ > 100 μM for inhibition of JMJD3/UTX).

Cell permeable ester derivative, GSK J5 and Active Analog also available.

Licensing Information

This compound is supplied in conjunction with the Structural Genomics Consortium. For further details of GSK J2, an inactive isomer of GSK J1, please visit the GSK J1 probe summary on the SGC website.

Technical Data for GSK J2

M. Wt	389.45
Formula	C₂₂H₂₃N₅O₂
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	1394854-52-4
PubChem ID	73010924
InChi Key	LJIFOCRGDDQFJF-UHFFFAOYSA-N
Smiles	O=C(CCNC1=NC(C2=CC=CN=C2)=NC(N3CCC(C=CC=C4)=C4CC3)=C1)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GSK J2

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	38.94	100
	1eq. HCl	19.47	50

Preparing Stock Solutions for GSK J2

The following data is based on the product molecular weight 389.45.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.57 mL	12.84 mL	25.68 mL
5 mM	0.51 mL	2.57 mL	5.14 mL
10 mM	0.26 mL	1.28 mL	2.57 mL
50 mM	0.05 mL	0.26 mL	0.51 mL

Molarity Calculator

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Reconstitution Calculator

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References for GSK J2

References are publications that support the biological activity of the product.

Kruidenier A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature 2012 PMID: 22842901