HBX 41108

Name: HBX 41108
Brand: Tocris Bioscience
SKU: 4285
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4285

(1)

Citations (13)

COA / SDS

Selective USP7 inhibitor

Key Product Details

Description:	Selective USP7 inhibitor
Chemical Name:	7-Chloro-9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile
Purity:	≥98% (HPLC)
Molecular Weight:	266.64

View Full Technical Details for HBX 41108

Technical Data
Citations / Reviews (1)

Biological Activity for HBX 41108

HBX 41108 is an inhibitor of ubiquitin-specific protease (USP) 7 activity (IC₅₀ = 424 nM). Displays uncompetitive inhibition. Also inhibits USP7-mediated p53 deubiquitination (IC₅₀ = 0.8 μM). Stabilizes p53 and inhibits cancer cell growth; induces p53-dependent apoptosis in p53 wild type and null isogenic cancer cell lines.

Licensing Information

Sold for research use only under patent license from Hybrigenics S.A.

Technical Data for HBX 41108

M. Wt	266.64
Formula	C₁₃H₃ClN₄O
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	924296-39-9
PubChem ID	16065773
InChi Key	BIGPXXAUSQLTQR-UHFFFAOYSA-N
Smiles	O=C2C1=CC(Cl)=CC=C1C3=C2N=C(C#N)C(C#N)=N3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for HBX 41108

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	26.66	100

Preparing Stock Solutions for HBX 41108

The following data is based on the product molecular weight 266.64.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.75 mL	18.75 mL	37.50 mL
5 mM	0.75 mL	3.75 mL	7.50 mL
10 mM	0.38 mL	1.88 mL	3.75 mL
50 mM	0.08 mL	0.38 mL	0.75 mL

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References for HBX 41108

References are publications that support the biological activity of the product.

Colombo Synthesis and biological evaluation of 9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile analogues as potential inhibitors of deubiquitinating enzymes. ChemMedChem 2010 PMID: 20186914
Colland Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells. Mol.Cancer Ther. 2009 PMID: 19671755