Herbimycin A

Name: Herbimycin A
Brand: Tocris Bioscience
SKU: 1629
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1629

(1)

Citations (7)

COA / SDS

Src family kinase inhibitor. Also Hsp90 inhibitor

Key Product Details

Description:	Src family kinase inhibitor. Also Hsp90 inhibitor
Chemical Name:	(15R)-17-demethoxy-15-methoxy-11-O-methyl-geldanamycin
Purity:	≥95% (HPLC)
Molecular Weight:	574.67

View Full Technical Details for Herbimycin A

Technical Data
Citations / Reviews (1)

Biological Activity for Herbimycin A

Herbimycin A is an ansamycin antibiotic that acts as a Src family kinase inhibitor. Binds to the SH domain and inhibits the activity of p60^v-src and p210^BCR-ABL. Exhibits antiangiogenic activity in endothelial cells in vitro. Also inhibits Hsp90 and impairs recovery from heat shock.

Technical Data for Herbimycin A

M. Wt	574.67
Formula	C₃₀H₄₂N₂O₉
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	70563-58-5
PubChem ID	6436247
InChi Key	MCAHMSDENAOJFZ-GDYSMBPZSA-N
Smiles	O=C1C=C([C@H](OC)[C@@H](C)C[C@H](OC)[C@H](OC)[C@@H](C)/C=C(C)/[C@H](OC(N)=O)[C@@H](OC)/C=C/C=C(C)/C2=O)C(C(N2)=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Herbimycin A

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	1

Preparing Stock Solutions for Herbimycin A

The following data is based on the product molecular weight 574.67.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.02 mM	87.01 mL	435.03 mL	870.06 mL
0.1 mM	17.40 mL	87.01 mL	174.01 mL
0.2 mM	8.70 mL	43.50 mL	87.01 mL
1 mM	1.74 mL	8.70 mL	17.40 mL

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References for Herbimycin A

References are publications that support the biological activity of the product.

McCollum Herbimycin A inhibits angiogenic activity in endothelial cells and reduces neovascularization in a rat model of retinopathy of prematurity. Exp.Eye Res. 2004 PMID: 15051479
Duncan Inhibition of Hsp90 function delays and impairs recovery from heat shock. FEBS J. 2005 PMID: 16218955
Fukazawa Labeling of v-Src and BCR-ABL tyrosine kinases with [¹⁴C]herbimycin A and its use in the elucidation of the kinase inactivation mechanism. FEBS Lett. 1994 PMID: 8131836