Idasanutlin

Name: Idasanutlin
Brand: Tocris Bioscience
SKU: 6904

Tocris Bioscience, part of Bio-Techne | Catalog # 6904

Citations (2)

COA / SDS

Potent MDM2 inhibitor; inhibits MDM2-p53 interaction

Key Product Details

Description:	Potent MDM2 inhibitor; inhibits MDM2-p53 interaction
Chemical Name:	4-[[[(2R,3S,4R,5S)-3-(3-Chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)-2-pyrrolidinyl]carbonyl]amino]-3-methoxybenzoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	616.49

View Full Technical Details for Idasanutlin

Technical Data
Citations

Biological Activity for Idasanutlin

Idasanutlin is a potent MDM2 inhibitor (IC₅₀ = 6 nM in binding assay, and 30 nM in cancer cell proliferation assay). Induces p53 stabilisation, cell cycle arrest and apoptosis in cancer cells expressing wildtype p53. Displays inhibition of tumor growth in the SJSA1 tumor xenograft model. Also inhibits MDR-1 at high concentrations.

Compound Libraries for Idasanutlin

Idasanutlin is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for Idasanutlin

M. Wt	616.49
Formula	C₃₁H₂₉Cl₂F₂N₃O₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1229705-06-9
PubChem ID	53358942
InChi Key	TVTXCJFHQKSQQM-LJQIRTBHSA-N
Smiles	COC1=C(C=CC(C(O)=O)=C1)NC([C@@H]2N[C@H]([C@@]([C@H]2C3=C(C(Cl)=CC=C3)F)(C4=C(C=C(C=C4)Cl)F)C#N)CC(C)(C)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Idasanutlin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	61.65	100

Preparing Stock Solutions for Idasanutlin

The following data is based on the product molecular weight 616.49.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.62 mL	8.11 mL	16.22 mL
5 mM	0.32 mL	1.62 mL	3.24 mL
10 mM	0.16 mL	0.81 mL	1.62 mL
50 mM	0.03 mL	0.16 mL	0.32 mL

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References for Idasanutlin

References are publications that support the biological activity of the product.

Chen Structurally diverse MDM2-p53 antagonists act as modulators of MDR-1 function in neuroblastoma. Br.J.Cancer. 2014 PMID: 24921920
Ding Discovery of RG7388, a potent and selective p53-MDM2 inhibitor in clinical development. J.Med.Chem. 2013 PMID: 23808545