Ubiquitin Ligase (E3) Inhibitors: Small Molecules and Peptides
39 results for "Ubiquitin Ligase (E3) Inhibitors Small Molecules and Peptides" in Products
39 results for "Ubiquitin Ligase (E3) Inhibitors Small Molecules and Peptides" in Products
Ubiquitin Ligase (E3) Inhibitors: Small Molecules and Peptides
MDM2 antagonist; inhibits MDM2-p53 interaction
Chemical Name: | (±)-4-[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-2-one |
Purity: | ≥98% (HPLC) |
HECT E3 ubiquitin ligase inhibitor
Chemical Name: | N-(4-Acetylphenyl)-3-(5-ethyl-2-furanyl)-2-propenamide |
Purity: | ≥98% (HPLC) |
SPOP E3 ubiquitin ligase inhibitor
Chemical Name: | 1,5-Dihydro-2-imino-10-methyl-N-[2-(4-methyl-1-piperazinyl)ethyl]-5-oxo-1-[2-(2-thienyl)ethyl]-2H-dipyrido[1,2-a:2',3'-d]pyrimidine-3-carboxamide |
Purity: | ≥98% (HPLC) |
Cereblon binder; induces ubiquitination and degradation of CK1α by E3 ubiquitin ligase
Chemical Name: | 3-(4-Amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione |
Purity: | ≥98% (HPLC) |
β-TrCP1 ligase inhibitor
Chemical Name: | 4-[4-[[5-(2-Fluorophenyl)-2-furanyl]methylene]-4,5-dihydro-5-oxo-3-(phenylmethyl)-1H-pyrazol-1-yl]benzoic acid |
Purity: | ≥98% (HPLC) |
Inhibitor of Bmi1/Ring1A; blocks histone H2A ubiquitination
Chemical Name: | 2-(3-Pyridinylmethylene)-1H-Indene-1,3(2H)-dione |
Purity: | ≥99% (HPLC) |
Cdc20 inhibitor; inhibits Cdc20-substrate interaction
Chemical Name: | 3-(2-Methyl-5-nitroimidazol-1-yl)-N-(2,2,2-trichloro-1-phenylaminoethyl)propionamide |
Purity: | ≥98% (HPLC) |
Selective Skp2 inhibitor; suppresses E3 ligase activity
Chemical Name: | 3-(2-Benzothiazolyl)-6-ethyl-7-hydroxy-8-(1-piperidinylmethyl)-4H-1-benzopyran-4-one |
Purity: | ≥98% (HPLC) |
(+)-JQ1 based Degrader (PROTAC®) that preferentially degrades BRD4
Chemical Name: | (2S,4R)-1-((S)-2-(tert-butyl)-17-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecanoyl)- 4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide |
Purity: | ≥98% (HPLC) |
CHIP/STUB1 E3 ligase inhibitor
Purity: | ≥95% (HPLC) |
Selective GID4 antagonist
Chemical Name: | N-((1s,4s)-4-(1H-Benzo[d]imidazol-2-yl)cyclohexyl)-2-(((1H-indol-2-yl)methyl)amino)acetamide dihydrochloride |
Purity: | ≥98% (HPLC) |
Potent and selective CSN5 (COP9 signalosome) inhibitor
Chemical Name: | 3-(Difluoromethyl)-N-(6-((5S,6S)-6-hydroxy-6,7,8,9-tetrahydro-5H-imidazo[1,5-a]azepin-5-yl)-[1,10-biphenyl]-3-yl)-1-isopropyl-1H-pyrazole-5-carboxamide |
Purity: | ≥98% (HPLC) |
MDM2-p53 interaction inhibitor
Alternate Names: | NSC 652287 |
Chemical Name: | 5,5'-(2,5-Furandiyl)bis-2-thiophenemethanol |
Purity: | ≥97% (HPLC) |
Selective CUL4 inhibitor
Chemical Name: | 3-[1-(4-Chlorophenyl)-1H-pyrazol-4-yl]-7,8-dihydroxy-2-(trifluoromethyl)-4H-1-benzopyran-4-one |
Purity: | ≥98% (HPLC) |
Potent and selective cereblon Degrader (PROTAC®); cell-permeable
Chemical Name: | (2S,4R)-1-((2S)-2-(5-((5-((6-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)hexyl)oxy)pentyl)oxy)pentanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide |
Purity: | ≥96% (HPLC) |
High-affinity inhibitor of VHL
Chemical Name: | (2S,4R)-1-((S)-2-(1-cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide |
Purity: | ≥98% (HPLC) |
Cereblon binder; also TNF-α inhibitor and antiangiogenic
Chemical Name: | 4-Amino-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione |
Purity: | ≥98% (HPLC) |
MDM2 antagonist; active enantiomer of Nutlin-3 (Cat. No. 3984)
Chemical Name: | 4-[[(4S,5R)-4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone |
Purity: | ≥97% (HPLC) |
SKP2 (S-phase kinase-associated protein 2) inhibitor; upregulates p27 and arrests cell cycle in G1 phase
Chemical Name: | N-(4-Butyl-2-methylphenyl)acetamide |
Purity: | ≥98% (HPLC) |
Hdm2 inhibitor; activates p53-dependent transcription
Chemical Name: | 5-[[3-Dimethylamino)propyl]amino]-3,10-dimethylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dione dihydrochloride |
Purity: | ≥99% (HPLC) |
RNF114 inhibitor
Chemical Name: | (2aR,5aR,6S,6aR,8R,9aR,10aS,10bR,10cR)-8-(3-Furanyl)-2a,5a,6,6a,8,9,9a,10a,10b,10c-decahydro-2a,5a,6a,7-tetramethyl-2,5-dioxo-2H,5H-cyclopenta[d']naphtho[1,8-bc:2,3-b']difuran-6-acetic acid methyl ester |
Purity: | ≥97% (HPLC) |
Molecular glue; pre-mRNA splicing modulator
Chemical Name: | N1-(3-Chloro-1H-indol-7-yl)-1,4-benzenedisulfonamide |
Purity: | ≥98% (HPLC) |
High affinity MDM2 inhibitor
Chemical Name: | 6-Methoxy-1-(1-naphthalenyl)-9H-pyrido[3,4-b]indole |
Purity: | ≥98% (HPLC) |
Potent MDM2 inhibitor; inhibits MDM2-p53 interaction
Chemical Name: | 4-[[[(2R,3S,4R,5S)-3-(3-Chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)-2-pyrrolidinyl]carbonyl]amino]-3-methoxybenzoic acid |
Purity: | ≥98% (HPLC) |
TRAF6-Ubc13 interaction inhibitor
Chemical Name: | 3-[3,5-Dimethyl-1-(3-methyl-1,2,4-triazolo[4,3-b]pyridazin-6-yl)-1H-pyrazol-4-yl]-1-[4-(phenylmethyl)-1-piperidinyl]-1-propanone |
Purity: | ≥98% (HPLC) |