IKK 16

Name: IKK 16
Brand: Tocris Bioscience
SKU: 2539
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2539

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Citations (30)

COA / SDS

Selective inhibitor of IKK

Key Product Details

Description:	Selective inhibitor of IKK
Chemical Name:	N-(4-Pyrrolidin-1-yl-piperidin-1-yl)-[4-(4-benzo[b]thiophen-2-yl-pyrimidin-2-ylamino)phenyl]carboxamide hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	520.09

View Full Technical Details for IKK 16

Technical Data
Citations / Reviews (1)

Biological Activity for IKK 16

IKK 16 is a selective inhibitor of IκB kinase (IKK) (IC₅₀ values are 40, 70 and 200 nM for IKKβ, IKK complex and IKKα respectively). Inhibits TNF-α-stimulated IκB degradation and expression of adhesion molecules E-selectin, ICAM and VCAM (IC₅₀ values are 1.0, 0.5, 0.3 and 0.3 μM respectively). Inhibits LPS-induced TNF-α release in vivo and neutrophil extravasion in thioglycollate-induced peritonitis.

Compound Libraries for IKK 16

IKK 16 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for IKK 16

M. Wt	520.09
Formula	C₂₈H₂₉N₅OS.HCl
Storage	Desiccate at -20°C
Purity	≥98% (HPLC)
CAS Number	1186195-62-9
PubChem ID	56972179
InChi Key	XFVDIVQCZWDBCW-UHFFFAOYSA-N
Smiles	Cl.O=C(N1CCC(CC1)N1CCCC1)C1=CC=C(NC2=NC=CC(=N2)C2=CC3=CC=CC=C3S2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for IKK 16

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	26	50
	DMSO	26	50

Preparing Stock Solutions for IKK 16

The following data is based on the product molecular weight 520.09.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	3.85 mL	19.23 mL	38.45 mL
2.5 mM	0.77 mL	3.85 mL	7.69 mL
5 mM	0.38 mL	1.92 mL	3.85 mL
25 mM	0.08 mL	0.38 mL	0.77 mL

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References for IKK 16

References are publications that support the biological activity of the product.

Waelchli Design and preparation of 2-benzoamido-pyrimidines as inhibitors of IKK. Bioorg.Med.Chem.Lett. 2006 PMID: 16236504