Impentamine dihydrobromide

Name: Impentamine dihydrobromide
Brand: Tocris Bioscience
SKU: 1858

Tocris Bioscience, part of Bio-Techne | Catalog # 1858

COA / SDS

Selective H3 antagonist

Discontinued Product

1858 has been discontinued. View all Histamine H3 Receptor Antagonists products.

Key Product Details

Description:	Selective H₃ antagonist
Alternative Names:	VUF 4702
Chemical Name:	4-(5-Aminopentyl)imidazole dihydrobromide
Molecular Weight:	315.05

View Full Technical Details for Impentamine dihydrobromide

Technical Data
Citations

Biological Activity for Impentamine dihydrobromide

Impentamine dihydrobromide is a potent and highly selective histamine H₃ receptor antagonist (pA₂ = 8.4); displays > 30000-fold selectivity over H₁ and H₂ receptors. Can act as a partial agonist in SK-N-MC cells expressing human H₃ receptors. Produces antinociception, possibly via a non-H₁, -H₂ or -H₃ receptor-mediated mechanism, following central administration in vivo.

Technical Data for Impentamine dihydrobromide

M. Wt	315.05
Formula	C₈H₁₅N₃.2HBr
Storage	Desiccate at RT
CAS Number	149629-70-9
PubChem ID	53439849
InChi Key	QSDXAAWBBPWGEL-UHFFFAOYSA-N
Smiles	Br.Br.NCCCCCC1=CN=CN1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Impentamine dihydrobromide

References are publications that support the biological activity of the product.

Vollinga Homologs of histamine as histamine H₃ receptor antagonists: a new potent and selective H₃ antagonist, 4(5)-(5-aminopentyl)-1H-imidazole. J.Med.Chem. 1995 PMID: 7830269
Wieland Constitutive activity of histamine H₃ receptors stably expressed in SK-N-MC cells: display of agonism and inverse agonism by H₃ antagonists. J.Pharmacol.Exp.Ther. 2001 PMID: 11714875
Hough Antinociceptive activity of impentamine, a histamine congener, after CNS administration. Life Sci. 1999 PMID: 10072195

Impentamine dihydrobromide

Tocris Bioscience, part of Bio-Techne | Catalog # 1858

Key Product Details

Biological Activity for Impentamine dihydrobromide

Technical Data for Impentamine dihydrobromide

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Impentamine dihydrobromide

Product Documents for Impentamine dihydrobromide

COA

Certificate of Analysis

SDS

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