Ivosidenib

Name: Ivosidenib
Brand: Tocris Bioscience
SKU: 7761

Tocris Bioscience, part of Bio-Techne | Catalog # 7761

COA / SDS

Potent inhibitor of mutant isocitrate dehydrogenase (mIDH1)

Key Product Details

Description:	Potent inhibitor of mutant isocitrate dehydrogenase (mIDH1)
Chemical Name:	(2S)-N-{(1S)-1-(2-Chlorophenyl)-2-[(3,3-difluorocyclobutyl)amino]-2-oxoethyl}-1(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	582.96

View Full Technical Details for Ivosidenib

Technical Data
Citations

Biological Activity for Ivosidenib

Ivosidenib is a potent inhibitor of mutant isocitrate dehydrogenase enzyme 1 (mIDH1), with activity against a variety of mutant IDH1 enzymes (IC₅₀ range = 5-19 nM). Reduces intracellular 2-HG (Cat. No. 6122) by 96% at 0.5 μM. Increases sensitivity of melanoma to Temozolomide (Cat. No. 2706) in vivo and inhibits wild-type IDH1 in low magnesium and low nutrient levels. Ivosidenib also inhibits growth of tumors in cell and animal models of pancreatic cancer and inhibits invasion and migration of chondrosarcoma cells in vitro.

Technical Data for Ivosidenib

M. Wt	582.96
Formula	C₂₈H₂₂ClF₃N₆O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1448347-49-6
PubChem ID	71657455
InChi Key	WIJZXSAJMHAVGX-DHLKQENFSA-N
Smiles	N([C@H](C(NC1CC(F)(F)C1)=O)C2=C(Cl)C=CC=C2)(C(=O)[C@H]3N(C(=O)CC3)C4=CC(C#N)=CC=N4)C=5C=C(F)C=NC5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Ivosidenib

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	58.3	100
	ethanol	58.3	100

Preparing Stock Solutions for Ivosidenib

The following data is based on the product molecular weight 582.96.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.72 mL	8.58 mL	17.15 mL
5 mM	0.34 mL	1.72 mL	3.43 mL
10 mM	0.17 mL	0.86 mL	1.72 mL
50 mM	0.03 mL	0.17 mL	0.34 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for Ivosidenib

References are publications that support the biological activity of the product.

Zarei Wild-type IDH1 inhibition enhances chemotherapy response in melanoma. J.Exp.Clin.Cancer Res. 2022 PMID: 36153582
Popovici-Muller Discovery of AG-120 (ivosidenib): a first-in-class mutant IDH1 inhibitor for the treatment of IDH1 mutant cancers. ACS Med.Chem.Lett. 2018 PMID: 29670690