J 113863

Name: J 113863
Brand: Tocris Bioscience
SKU: 2595
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2595

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Citations (23)

COA / SDS

Potent CCR1 chemokine receptor antagonist

Key Product Details

Description:	Potent CCR1 chemokine receptor antagonist
Chemical Name:	1,4-cis-1-(1-Cycloocten-1-ylmethyl)-4-[[(2,7-dichloro-9H-xanthen-9-yl)carbonyl]amino]-1-ethylpiperidinium iodide
Purity:	≥98% (HPLC)
Molecular Weight:	655.44

View Full Technical Details for J 113863

Technical Data
Citations / Reviews (1)

Biological Activity for J 113863

J 113863 is a potent chemokine receptor 1 (CCR1) antagonist (IC₅₀ values are 0.9 and 5.8 nM for human and mouse CCR1 receptors respectively). Also displays high selectivity for human but not mouse CCR3 receptors (IC₅₀ values are 0.58 and 460 nM respectively). Improves paw inflammation, joint damage and dramatically reduces cell infiltration into joints in collagen-induced arthritis in mice.

Isomer also available.

Technical Data for J 113863

M. Wt	655.44
Formula	C₃₀H₃₇Cl₂IN₂O₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	202796-41-6
PubChem ID	6918496
InChi Key	FOAFBMYSXIGAOX-LQGGPMKRSA-N
Smiles	ClC1=CC=C(OC(C=CC(Cl)=C3)=C3C2C(N[C@@H]4CC[N@@+](C/C5=C/CCCCCC5)(CC)CC4)=O)C2=C1.ClC6=CC=C(OC(C=CC(Cl)=C8)=C8C7C(N[C@H]9CC[N@+](C/C%10=C/CCCCCC%10)(CC)CC9)=O)C7=C6.[I-].[I-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for J 113863

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	65.54	100
	ethanol	32.77	50

Preparing Stock Solutions for J 113863

The following data is based on the product molecular weight 655.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.53 mL	7.63 mL	15.26 mL
5 mM	0.31 mL	1.53 mL	3.05 mL
10 mM	0.15 mL	0.76 mL	1.53 mL
50 mM	0.03 mL	0.15 mL	0.31 mL

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References for J 113863

References are publications that support the biological activity of the product.

Amat Pharmacological blockade of CCR1 ameliorates murine arthritis and alters cytokine networks in vivo. Br.J.Pharmacol. 2006 PMID: 17016504
Naya Design, synthesis, and discovery of a novel CCR1 antagonist. J.Med.Chem. 2001 PMID: 11311066