UCB 35625

Name: UCB 35625
Brand: Tocris Bioscience
SKU: 2757

Tocris Bioscience, part of Bio-Techne | Catalog # 2757

Citations (15)

COA / SDS

Potent CCR1 and CCR3 antagonist

Key Product Details

Description:	Potent CCR1 and CCR3 antagonist
Chemical Name:	1,4-trans-1-(1-Cycloocten-1-ylmethyl)-4-[[(2,7-dichloro-9H-xanthen-9-yl)carbonyl]amino]-1-ethylpiperidinium iodide
Purity:	≥98% (HPLC)
Molecular Weight:	655.44

View Full Technical Details for UCB 35625

Technical Data
Citations

Biological Activity for UCB 35625

UCB 35625 is a potent chemokine CCR1 and CCR3 receptor antagonist. Inhibits MIP-1α-induced chemotaxis in CCR1 transfectants and eotaxin-induced chemotaxis in CCR3 transfectants (IC₅₀ values are 9.57 and 93.8 nM respectively). Antagonizes CCR3-mediated entry of HIV-1 isolate 89.6 into NP-2 cells (IC₅₀ = 57 nM).

Isomer also available.

Compound Libraries for UCB 35625

UCB 35625 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for UCB 35625

M. Wt	655.44
Formula	C₃₀H₃₇Cl₂IN₂O₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	202796-42-7
PubChem ID	6918496
InChi Key	FOAFBMYSXIGAOX-LQGGPMKRSA-N
Smiles	ClC1=CC=C(OC(C=CC(Cl)=C3)=C3C2C(N[C@H]4CC[N@@+](C/C5=C/CCCCCC5)(CC)CC4)=O)C2=C1.ClC6=CC=C(OC(C=CC(Cl)=C8)=C8C7C(N[C@@H]9CC[N@+](C/C%10=C/CCCCCC%10)(CC)CC9)=O)C7=C6.[I-].[I-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for UCB 35625

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	65.54	100
	ethanol	32.77	50

Preparing Stock Solutions for UCB 35625

The following data is based on the product molecular weight 655.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.53 mL	7.63 mL	15.26 mL
5 mM	0.31 mL	1.53 mL	3.05 mL
10 mM	0.15 mL	0.76 mL	1.53 mL
50 mM	0.03 mL	0.15 mL	0.31 mL

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Reconstitution Calculator

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References for UCB 35625

References are publications that support the biological activity of the product.

Lopes de Mendonca Site-directed mutagenesis of CC chemokine receptor 1 reveals the mechanism of action of UCB 35625, a small molecule chemokine receptor antagonist. J.Biol.Chem. 2005 PMID: 15548526
Sabroe A small molecule antagonist of chemokine receptors CCR1 and CCR3. J.Biol.Chem. 2000 PMID: 10854442