JNJ 47965567

Name: JNJ 47965567
Brand: Tocris Bioscience
SKU: 5299

Tocris Bioscience, part of Bio-Techne | Catalog # 5299

(3)

Citations (29)

COA / SDS

Potent and selective P2X7 antagonist; brain penetrant

Key Product Details

Chemical Name:	2-(Phenylthio)-N-[[tetrahydro-4-(4-phenyl-1-piperazinyl)-2H-pyran-4-yl]methyl-3-pyridinecarboxamide
Purity:	≥98%

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Technical Data
Citations / Reviews (3)

Biological Activity for JNJ 47965567

JNJ 47965567 is a potent and selective P2X₇ antagonist (pIC₅₀ values are 8.3, 7.5 and 7.2 for human, mouse and rat receptors respectively). Selective over a panel of 50 other receptors, ion channels and transporters. Reduces BzATP-induced IL-1β release from monocytes in vitro and from rat brain in vivo. Attenuates amphetamine-induced hyperactivity in rats. Brain penetrant.

Technical Data for JNJ 47965567

Formula	C₂₈H₃₂N₄O₂S
Storage	Store at +4°C
Purity	≥98%
CAS Number	1428327-31-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for JNJ 47965567

Solubility

Soluble Soluble to 50 mM in 1eq. HCl and to 100 mM in DMSO

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References for JNJ 47965567

References are publications that support the biological activity of the product.

Bhattacharya et al. Pharmacological characterization of a novel centrally permeable P2X₇ receptor antagonist: JNJ-47965567. Br.J.Pharmacol., 2013;170:624 PMID: 23889535
Letavic et al. Synthesis and pharmacological characterization of two novel, brain penetrating P2X₇ antagonists. ACS Med.Chem.Lett., 2013;12:419 PMID: 24900687

JNJ 47965567

Tocris Bioscience, part of Bio-Techne | Catalog # 5299

Key Product Details

Biological Activity for JNJ 47965567

Technical Data for JNJ 47965567

Solubility for JNJ 47965567

Dilution Calculator

Reconstitution Calculator

References for JNJ 47965567

Product Documents for JNJ 47965567

COA

Certificate of Analysis

SDS

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