JNJ 5207852 dihydrochloride

Name: JNJ 5207852 dihydrochloride
Brand: Tocris Bioscience
SKU: 4020

Tocris Bioscience, part of Bio-Techne | Catalog # 4020

Citations (2)

COA / SDS

High affinity H3 antagonist

Key Product Details

Chemical Name:	1-[3-[4-(1-Piperidinylmethyl)phenoxy]propyl]piperidine hydrochloride
Purity:	≥99%
Molecular Weight:	389.4 kDa

View Full Technical Details for JNJ 5207852 dihydrochloride

Technical Data
Citations

Biological Activity for JNJ 5207852 dihydrochloride

JNJ 5207852 dihydrochloride is a high affinity histamine H₃ receptor neutral antagonist (pK_i values are 8.9 and 9.2 in rat and human respectively). Brain penetrant and orally active. Has 3- and 100-fold higher affinity than thioperamide (Cat. No. 0644) for rat and human H₃ receptors respectively. Suppresses slow-wave sleep; exhibits wake-promoting effects in rodent arousal models.

Technical Data for JNJ 5207852 dihydrochloride

M. Wt	389.4 kDa
Formula	C₂₀H₃₂N₂O.2HCl
Storage	Desiccate at RT
Purity	≥99%
CAS Number	1782228-76-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for JNJ 5207852 dihydrochloride

Solubility

Soluble Soluble to 50 mM in water and to 20 mM in DMSO with gentle warming

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References for JNJ 5207852 dihydrochloride

References are publications that support the biological activity of the product.

Barbier et al. Acute wake-promoting actions of JNJ-5207852, a novel, diamine-based H₃ antagonist. Br.J.Pharmacol., 2004;143:649 PMID: 15466448
Le et al. Correlation between ex vivo receptor occupancy and wake-promoting activity of selective H₃ receptor antagonists. J.Pharmacol.Exp.Ther., 2008;325:902 PMID: 18305012
Jia et al. Effects of histamine H₃ antagonists and donep. on learning and mnemonic deficits induced by pentylenetetrazol kindling in weanling mice. Neuropharmacology, 2005;50:404 PMID: 16310812