Kisspeptin 10 (human)

Name: Kisspeptin 10 (human)
Brand: Tocris Bioscience
SKU: 2570

Tocris Bioscience, part of Bio-Techne | Catalog # 2570

Citations (10)

COA / SDS

Endogenous ligand for kisspeptin receptor

Key Product Details

Description:	Endogenous ligand for kisspeptin receptor
Alternative Names:	Metastin (45-54),Kp-10
Purity:	≥95% (HPLC)
Molecular Weight:	1302.45

View Full Technical Details for Kisspeptin 10 (human)

Technical Data
Citations

Biological Activity for Kisspeptin 10 (human)

Kisspeptin 10 (human) is a potent endogenous ligand for the Kisspeptin receptor (KISS1, GPR54). Binds with high affinity to rat and human KISS1 receptors with K_i values of 1.59 and 2.33 nM respectively. Inhibits metastasis and invasion in mouse melanomas and stimulates gonadotropin secretion following i.c.v. administration.

Analog also available.

Technical Data for Kisspeptin 10 (human)

M. Wt	1302.45
Formula	C₆₃H₈₃N₁₇O₁₄
Single Letter Sequence	YNWNSFGLRF (Modification: Phe-10 = C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	374675-21-5
PubChem ID	25240297
InChi Key	RITKWYDZSSQNJI-INXYWQKQSA-N
Smiles	[H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Kisspeptin 10 (human)

Solubility

Soluble to 1mg/ml in water

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References for Kisspeptin 10 (human)

References are publications that support the biological activity of the product.

Peilecka-Fortuna Kisspeptin acts directly and indirectly to increase GnRH neuron activity and its effects are modulated by OE. Endocrinology 2007 PMID: 18162521
Becker Activation of GPR54 promotes cell cycle arrest and apoptosis of human tumour cells through a specific transcriptional program not shared by other G_q-coupled receptors. Biochem.Biophys.Res.Comm.
Kotani The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54. J.Biol.Chem. 2001 PMID: 11457843