KN 92

Name: KN 92
Brand: Tocris Bioscience
SKU: 4130
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4130

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Citations (31)

COA / SDS

Inactive analog of KN 93. K+ channel (Kv) blocker

Key Product Details

Description:	Inactive analog of KN 93. K⁺ channel (K_v) blocker
Chemical Name:	2-[N-(4'-Methoxybenzenesulfonyl)]amino-N-(4'-chlorophenyl)-2-propenyl-N-methylbenzylamine phosphate
Purity:	≥98% (HPLC)
Molecular Weight:	554.98

View Full Technical Details for KN 92

Technical Data
Citations / Reviews (1)

Biological Activity for KN 92

KN 92 is an inactive analog of the CaM kinase II inhibitor KN 93 . Potassium channel (K_v1.2, 1.4, 1.5, 2.1, 3.2 and hERG) blocker in vitro.

Active Analog also available.

Technical Data for KN 92

M. Wt	554.98
Formula	C₂₄H₂₅ClN₂O₃S.H₃PO₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1135280-28-2
PubChem ID	16219540
InChi Key	XRQHWVVDNMJDEQ-IPZCTEOASA-N
Smiles	ClC1=CC=C(/C=C/CN(C)CC2=CC=CC=C2NS(=O)(C3=CC=C(OC)C=C3)=O)C=C1.OP(O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for KN 92

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	5.55	10

Preparing Stock Solutions for KN 92

The following data is based on the product molecular weight 554.98.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.02 mL	90.09 mL	180.19 mL
0.5 mM	3.60 mL	18.02 mL	36.04 mL
1 mM	1.80 mL	9.01 mL	18.02 mL
5 mM	0.36 mL	1.80 mL	3.60 mL

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References for KN 92

References are publications that support the biological activity of the product.

Rezazadeh KN-93 (2-[N-(2-hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine), a calcium/calmodulin-dependent protein kinase II inhibitor, is a direct extracellular blocker of voltage-gated J.Pharmacol.Exp.Ther. 2005 PMID: 16368898