KN 93

Name: KN 93
Brand: Tocris Bioscience
SKU: 1278
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1278

(1)

Citations (155)

COA / SDS

CaM kinase II inhibitor; also K+ channel blocker (KV)

Key Product Details

Description:	CaM kinase II inhibitor; also K⁺ channel blocker (K_V)
Chemical Name:	N-[2-[[[3-(4-Chlorophenyl)-2-propenyl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulphonamide
Purity:	≥98% (HPLC)
Molecular Weight:	501.04

View Full Technical Details for KN 93

Technical Data
Citations / Reviews (1)

Biological Activity for KN 93

KN 93 is a potent, cell permeable inhibitor of CaM kinase II (IC₅₀ = 0.37 μM). Also a direct extracellular open channel blocker of voltage-gated potassium channels (IC₅₀ = 307 nM for K_V1.5) and abolishes IKr in ventricular myocytes (IC₅₀ = 102.6 nM) independently of CaM kinase II inhibition.

Water soluble form and Negative Control also available.

Technical Data for KN 93

M. Wt	501.04
Formula	C₂₆H₂₉ClN₂O₄S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	139298-40-1
PubChem ID	5312122
InChi Key	LLLQTDSSHZREGW-AATRIKPKSA-N
Smiles	O=S(N(CCO)C1=C(CN(C)C/C=C/C3=CC=C(Cl)C=C3)C=CC=C1)(C2=CC=C(OC)C=C2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for KN 93

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	50.1	100 with gentle warming

Preparing Stock Solutions for KN 93

The following data is based on the product molecular weight 501.04.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.00 mL	9.98 mL	19.96 mL
5 mM	0.40 mL	2.00 mL	3.99 mL
10 mM	0.20 mL	1.00 mL	2.00 mL
50 mM	0.04 mL	0.20 mL	0.40 mL

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References for KN 93

References are publications that support the biological activity of the product.

Hegyi KN-93 inhibits IKr in mammalian cardiomyocytes. J.Mol.Cell.Cardiol. 2015 PMID: 26463508
Rezazadeh KN-93 (2-[N-(2-Hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]-amino-N-(4-chlorocinnamyl)-N-methylbenzylamine), a calcium/calmodulin-dependent protein kinase II inhibitor, is a direct extracellular blocker of voltage-gated J.Pharmacol.Exp.Ther. 2006 PMID: 16368898
Sumi The newly synthesized selective Ca²⁺/calmodulin dependent protein kinase II inhibitor KN-93 reduces DA content in PC12h cells. Biochem.Biophys.Res.Comm. 1991 PMID: 1662507
Patel Calcium/calmodulin-dependent phosphorylation and activation of human Cdc25-C at the G₂/M phase transition in HeLa cells. J.Biol.Chem. 1999 PMID: 10075693