LDN 214117

Name: LDN 214117
Brand: Tocris Bioscience
SKU: 6152

Tocris Bioscience, part of Bio-Techne | Catalog # 6152

COA / SDS

Potent and selective ALK2 inhibitor

Discontinued Product

6152 has been discontinued. View all BMP and Other Activin Receptor Inhibitors products.

Key Product Details

Description:	Potent and selective ALK2 inhibitor
Chemical Name:	1-[4-[6-Methyl-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenyl]piperazine
Purity:	≥98% (HPLC)
Molecular Weight:	419.52

View Full Technical Details for LDN 214117

Technical Data
Citations

Biological Activity for LDN 214117

LDN 214117 is a potent and selective inhibitor of type I bone morphogenic protein (BMP) receptor ALK2 (IC₅₀ = 24 nM). Shows preference for ALK1 and ALK2 over ALK3 and 164-fold selectivity for BMP6 inhibition (IC₅₀ = 100 nM) over TGF-β1. Exhibits improved kinome selectivity over K 02288 (Cat.No. 4986) and low cytotoxicity.

Licensing Information

Sold for research purposes under exclusive agreement from The Brigham and Women's Hospital Inc. US patent 14/776,302

Technical Data for LDN 214117

M. Wt	419.52
Formula	C₂₅H₂₉N₃O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1627503-67-6
PubChem ID	91754554
InChi Key	BHUXVRVMMYAXKN-UHFFFAOYSA-N
Smiles	COC1=CC(C2=C(N=CC(C3=CC=C(N4CCNCC4)C=C3)=C2)C)=CC(OC)=C1OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for LDN 214117

References are publications that support the biological activity of the product.

Mohedas Structure-activity relationship of 3,5-diaryl-2-aminopyridine ALK2 inhibitors reveals unaltered binding affinity for fibrodysplasia ossificans progressiva causing mutants. J Med Chem. 2014 PMID: 25101911