Lenalidomide

Name: Lenalidomide
Brand: Tocris Bioscience
SKU: 6305

Tocris Bioscience, part of Bio-Techne | Catalog # 6305

(1)

Citations (7)

COA / SDS

Cereblon binder; induces ubiquitination and degradation of CK1α by E3 ubiquitin ligase

Key Product Details

Chemical Name:	3-(4-Amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione
Purity:	≥98%

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Technical Data
Citations / Reviews (1)

Biological Activity for Lenalidomide

Lenalidomide is a thalidomide analog. Immune modulatory drug and cereblon binding compound. Induces ubiquitination and degradation of casein kinase (CK) 1α by the E3 ubiquitin ligase CRL4^CRBN. Also TNF-α inhibitor and angiogenesis inhibitor. Promotes degradation of transcription factor SALL4.

Technical Data for Lenalidomide

Formula	C₁₃H₁₃N₃O₃
Storage	Store at -20°C
Purity	≥98%
CAS Number	191732-72-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Lenalidomide

Solubility

Soluble Soluble to 100 mM in DMSO

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References for Lenalidomide

References are publications that support the biological activity of the product.

Petzold et al. Structural basis of lenalidomide-induced CK1a degradation by the CRL4(CRBN) ubiquitin ligase. Nature, 2016;532:127 PMID: 26909574
Krönke et al. Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS. Nature, 2015;523:183 PMID: 26131937
Donovan et al. Thal. promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray Syndrome. Elife, 2018;7:e38430 PMID: 30067223
Chamberlain et al. Evolution of cereblon-mediated protein degradation as a therapeutic modality. ACS Med.Chem.Lett., 2019;10:1592 PMID: 31857833

Lenalidomide

Tocris Bioscience, part of Bio-Techne | Catalog # 6305

Key Product Details

Biological Activity for Lenalidomide

Technical Data for Lenalidomide

Solubility for Lenalidomide

Dilution Calculator

Reconstitution Calculator

References for Lenalidomide

Product Documents for Lenalidomide

COA

Certificate of Analysis

SDS

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