Lopinavir

Name: Lopinavir
Brand: Tocris Bioscience
SKU: 7052

Tocris Bioscience, part of Bio-Techne | Catalog # 7052

Citations (2)

COA / SDS

Highly potent and selective HIV-1 protease inhibitor

Key Product Details

Description:	Highly potent and selective HIV-1 protease inhibitor
Alternative Names:	ABT-378
Chemical Name:	(αS)-N-[(1S,3S,4S)-4-[[2-(2,6-Dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-α-(1-methylethyl)-2-oxo-1(2H)-pyrimidineacetamide
Purity:	≥98% (HPLC)
Molecular Weight:	628.8

View Full Technical Details for Lopinavir

Technical Data
Citations

Biological Activity for Lopinavir

Lopinavir is a highly potent and selective HIV-1 protease inhibitor (IC₅₀ = 6.5 nM, HIV cultured in peripheral blood mononuclear cells; K_i = 1.3 pM). Displays >10⁵-fold selectivity for HIV-1 protease over mammalian proteases including renin and cathepsin D and E. Inhibits HIV-1 protease in patient HIV isolates displaying mutations that confer resistance to ritonavir (Cat. No. 5856) (IC₅₀ values in 5 - 50 nM range). Also inhibits SARS-CoV-2 replication in vitro (IC₅₀ = 26 μM)

Compound Libraries for Lopinavir

Lopinavir is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for Lopinavir

M. Wt	628.8
Formula	C₃₇H₄₈N₄O₅
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	192725-17-0
PubChem ID	92727
InChi Key	KJHKTHWMRKYKJE-SUGCFTRWSA-N
Smiles	CC([C@@H](C(N[C@@H](CC1=CC=CC=C1)C[C@@H]([C@@H](NC(COC2=C(C=CC=C2C)C)=O)CC3=CC=CC=C3)O)=O)N4CCCNC4=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Lopinavir

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	62.88	100
	ethanol	62.88	100

Preparing Stock Solutions for Lopinavir

The following data is based on the product molecular weight 628.8.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.59 mL	7.95 mL	15.90 mL
5 mM	0.32 mL	1.59 mL	3.18 mL
10 mM	0.16 mL	0.80 mL	1.59 mL
50 mM	0.03 mL	0.16 mL	0.32 mL

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Reconstitution Calculator

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References for Lopinavir

References are publications that support the biological activity of the product.

Carrillo In vitro selection and characterization of human immunodeficiency virus type 1 variants with increased resistance to ABT-378, a novel protease inhibitor. J.Virol. 1998 PMID: 9696850
Choy Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro. Antiviral Res. 2020 PMID: 32251767
Sham ABT-378, a highly potent inhibitor of the human immunodeficiency virus protease. Antimicrob.Agents Chemother. 1998 PMID: 9835517