LY 294002 hydrochloride

Name: LY 294002 hydrochloride
Brand: Tocris Bioscience
SKU: 1130

Tocris Bioscience, part of Bio-Techne | Catalog # 1130

(7)

Citations (83)

COA / SDS

Prototypical PI 3-kinase inhibitor; also inhibits other kinases

Key Product Details

Chemical Name:	2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one hydrochloride
Purity:	≥99%
Molecular Weight:	343.81 kDa

View Full Technical Details for LY 294002 hydrochloride

Technical Data
Citations / Reviews (7)

Biological Activity for LY 294002 hydrochloride

LY 294002 hydrochloride is a prototypical PI 3-kinase inhibitor (IC₅₀ values are 0.31, 0.73, 1.06 and 6.60 μM for PI 3-Kβ, PI 3-Kα, PI 3-Kδ and PI 3-Kγ respectively). Also inhibits other kinases including, CK2, mTOR, PLK1, PIM1 and PIM3. Inhibits proliferation and induces apoptosis in human colon cancer cells in vitro and in vivo. Suppresses proliferation of mESCs. Inhibits autophagic sequestration in rat hepatocytes.

Negative Control also available.

Technical Data for LY 294002 hydrochloride

M. Wt	343.81 kDa
Formula	C₁₉H₁₇NO₃.HCl
Storage	Store at RT
Purity	≥99%
CAS Number	934389-88-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for LY 294002 hydrochloride

Solubility

Soluble Soluble to 25 mM in DMSO

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References for LY 294002 hydrochloride

References are publications that support the biological activity of the product.

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