LY 341495 disodium salt

Name: LY 341495 disodium salt
Brand: Tocris Bioscience
SKU: 4062

Tocris Bioscience, part of Bio-Techne | Catalog # 4062

Citations (6)

COA / SDS

Potent and selective group II mGlu antagonist; disodium salt of LY 341495 (Cat. No. 1209)

Key Product Details

Description:	Potent and selective group II mGlu antagonist; disodium salt of LY 341495 (Cat. No. 1209)
Chemical Name:	(2S)-2-Amino-2-[(1S,2S)-2-carboxycycloprop-1-yl]-3-(xanth-9-yl) propanoic acid disodium salt
Purity:	≥97% (HPLC)
Molecular Weight:	397.33

View Full Technical Details for LY 341495 disodium salt

Technical Data
Citations

Biological Activity for LY 341495 disodium salt

LY 341495 disodium salt is a Highly potent and selective group II metabotropic glutamate receptor antagonist. Disodium salt of LY 341495 (Cat. No. 1209).

Technical Data for LY 341495 disodium salt

M. Wt	397.33
Formula	C₂₀H₁₇NNa₂O₅
Storage	Store at -20°C
Purity	≥97% (HPLC)
PubChem ID	90488907
InChi Key	UYFREPWOVKMBOV-AUZVYACCSA-L
Smiles	[Na+].[Na+].[H][C@@]1(C[C@@H]1C([O-])=O)[C@@](N)(CC1C2=CC=CC=C2OC2=C1C=CC=C2)C([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for LY 341495 disodium salt

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	39.73	100

Preparing Stock Solutions for LY 341495 disodium salt

The following data is based on the product molecular weight 397.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.52 mL	12.58 mL	25.17 mL
5 mM	0.50 mL	2.52 mL	5.03 mL
10 mM	0.25 mL	1.26 mL	2.52 mL
50 mM	0.05 mL	0.25 mL	0.50 mL

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References for LY 341495 disodium salt

References are publications that support the biological activity of the product.

Ornstein 2-Substituted (2SR)-2-amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl) glycines as potent and selective antagonists of group II metabotropic glutamate receptors. 2. Effects of aromatic substitution, pharmacological characterization, and bioav J.Med.Chem. 1998 PMID: 9464367
Johnson [³H]-LY341495 as a novel antagonist radioligand for group II metabotropic glutamate receptors: characterization of binding to membranes of mGlu receptor subtype expressing cells. Neuropharmacology 1999 PMID: 10530814
Fitzjohn The potent mGlu receptor antagonist LY341495 identifies roles for both cloned and novel mGlu receptors in hippocampal synaptic plasticity. Neuropharmacology 1998 PMID: 9886667