LY 341495

Name: LY 341495
Brand: Tocris Bioscience
SKU: 1209
Rating: 5 (2 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1209

Citations (402)

COA / SDS

Highly potent and selective group II mGlu antagonist

Key Product Details

Description:	Highly potent and selective group II mGlu antagonist
Chemical Name:	(2S)-2-Amino-2-[(1S,2S)-2-carboxycycloprop-1-yl]-3-(xanth-9-yl) propanoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	353.37

View Full Technical Details for LY 341495

Technical Data
Citations

Biological Activity for LY 341495

LY 341495 is a highly potent and selective group II metabotropic glutamate receptor antagonist (K_i/IC₅₀ values are 2.3, 1.3, 173, 990, 6800, 8200 and 22000 nM for human mGlu₂, mGlu₃, mGlu₈, mGlu_7a, mGlu_1a, mGlu_5a and mGlu_4a receptors respectively). Readily brain penetrant and active in vivo.

Disodium salt (Cat. No. 4062) also available.

Licensing Information

Sold with the permission of Eli Lilly and Company

Technical Data for LY 341495

M. Wt	353.37
Formula	C₂₀H₁₉NO₅
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	201943-63-7
PubChem ID	9819927
InChi Key	VLZBRVJVCCNPRJ-KPHUOKFYSA-N
Smiles	[H][C@]4([C@@H]([C@](O)=O)C4)[C@](N)(C(O)=O)CC2C3=C(C=CC=C3)OC1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for LY 341495

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	1.77	5 with gentle warming
	1.2eq. NaOH	35.34	100

Preparing Stock Solutions for LY 341495

The following data is based on the product molecular weight 353.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.83 mL	14.15 mL	28.30 mL
5 mM	0.57 mL	2.83 mL	5.66 mL
10 mM	0.28 mL	1.41 mL	2.83 mL
50 mM	0.06 mL	0.28 mL	0.57 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for LY 341495

References are publications that support the biological activity of the product.

Ornstein 2-Substituted (2SR)-2-amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl) glycines as potent and selective antagonists of group II metabotropic glutamate receptors. 2. Effects of aromatic substitution, pharmacological characterization, and bioav J.Med.Chem. 1998 PMID: 9464367
Johnson [³H]-LY341495 as a novel antagonist radioligand for group II metabotropic glutamate receptors: characterization of binding to membranes of mGlu receptor subtype expressing cells. Neuropharmacology 1999 PMID: 10530814
Kingston LY341495 is a nanomolar potent and selective antagonist of group II metabotropic glutamate receptors. Neuropharmacology 1998 PMID: 9680254
Fitzjohn The potent mGlu receptor antagonist LY341495 identifies roles for both cloned and novel mGlu receptors in hippocampal synaptic plasticity. Neuropharmacology 1998 PMID: 9886667