M8 B hydrochloride

Name: M8 B hydrochloride
Brand: Tocris Bioscience
SKU: 5324

Tocris Bioscience, part of Bio-Techne | Catalog # 5324

Citations (1)

COA / SDS

Potent and selective TRPM8 channel blocker

Key Product Details

Chemical Name:	N-(2-Aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-2-thiophenecarboxamide hydrochloride
Purity:	≥99%

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Technical Data
Citations

Biological Activity for M8 B hydrochloride

M8 B hydrochloride is a potent and selective TRPM8 channel blocker. Blocks cold- and icilin-induced TRPM8 activation in vitro (IC₅₀ values are 7.8 and 26.9 nM respectively). Exhibits no effect at other TRP channels (IC₅₀ > 20 μM). Reduces body temperature in vivo.

Technical Data for M8 B hydrochloride

Formula	C₂₂H₂₄N₂O₃S.HCl
Storage	Store at +4°C
Purity	≥99%
CAS Number	883976-12-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for M8 B hydrochloride

Solubility

Soluble Soluble to 10 mM in water with sonication and to 100 mM in DMSO

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References for M8 B hydrochloride

References are publications that support the biological activity of the product.

Almeida et al. Pharmacological blockade of the cold receptor TRPM8 attenuates autonomic and behavioral cold defenses and decreases deep body temperature. J.Neurosci., 2012;32:2086 PMID: 22323721

M8 B hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 5324

Key Product Details

Biological Activity for M8 B hydrochloride

Technical Data for M8 B hydrochloride

Solubility for M8 B hydrochloride

Dilution Calculator

Reconstitution Calculator

References for M8 B hydrochloride

Product Documents for M8 B hydrochloride

COA

Certificate of Analysis

SDS

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