MR 24

Name: MR 24
Brand: Tocris Bioscience
SKU: 8122

Tocris Bioscience, part of Bio-Techne | Catalog # 8122

COA / SDS

Potent and selective MST3 kinase binding inhibitor

Key Product Details

Description:	Potent and selective MST3 kinase binding inhibitor
Chemical Name:	8-(4-Aminobutyl)-6-[2-chloro-4-(6-methylpyridin-2-yl)phenyl]-2-(1,3-dihydroxypropan-2-ylamino)pyrido[2,3-d]pyrimidin-7-one trihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	618.38

View Full Technical Details for MR 24

Technical Data
Citations

Biological Activity for MR 24

MR 24 is a potent and selective MST3 kinase binding inhibitor with >10 fold selectivity over MST4 (EC₅₀ values from NanoBRET assay are 57 nM and 583 nM for MST3 and MST4 respectively). MR 24 increases the number of cells in G₁ phase of cell cycle, is non-cytotoxic and cell permeable. Shows 90% stability over 1 hour in activated liver microsomes in vivo.

Technical Data for MR 24

M. Wt	618.38
Formula	C₂₆H₂₉ClN₆O₃.3HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
InChi Key	GDJVKNSFYAPEKT-UHFFFAOYSA-N
Smiles	CC1=CC=CC(C2=CC(Cl)=C(C3=CC(C=NC(NC(CO)CO)=N4)=C4N(CCCCN)C3=O)C=C2)=N1.Cl.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MR 24

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	30.92	50

Preparing Stock Solutions for MR 24

The following data is based on the product molecular weight 618.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	3.23 mL	16.17 mL	32.34 mL
2.5 mM	0.65 mL	3.23 mL	6.47 mL
5 mM	0.32 mL	1.62 mL	3.23 mL
25 mM	0.06 mL	0.32 mL	0.65 mL

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References for MR 24

References are publications that support the biological activity of the product.

Rak Development of selective pyrido[2,3.d]pyrimidin-7(8H).one-based mammalian STE20-Like (MST3/4) kinase inhibitors. J.Med.Chem.