MRT 68921 dihydrochloride

Name: MRT 68921 dihydrochloride
Brand: Tocris Bioscience
SKU: 5780

Tocris Bioscience, part of Bio-Techne | Catalog # 5780

Citations (8)

COA / SDS

ULK inhibitor

Key Product Details

Description:	ULK inhibitor
Chemical Name:	N-[3-[[5-Cyclopropyl-2-[(1,2,3,4-tetrahydro-2-methyl-6-isoquinolinyl)amino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	507.5

View Full Technical Details for MRT 68921 dihydrochloride

Technical Data
Citations

Biological Activity for MRT 68921 dihydrochloride

MRT 68921 dihydrochloride is a potent ULK inhibitor (IC₅₀ values are 1.1 and 2.9 nM for ULK2 and ULK1, respectively). Inhibits autophagy in mouse embryonic fibroblasts.

Technical Data for MRT 68921 dihydrochloride

M. Wt	507.5
Formula	C₂₅H₃₄N₆O.2HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	2080306-21-2
PubChem ID	124201611
InChi Key	NLKPLTWKINJHCK-UHFFFAOYSA-N
Smiles	CN1CCC2=CC(NC3=NC=C(C(NCCCNC(C4CCC4)=O)=N3)C5CC5)=CC=C2C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MRT 68921 dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	50.75	100

Preparing Stock Solutions for MRT 68921 dihydrochloride

The following data is based on the product molecular weight 507.5.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.97 mL	9.85 mL	19.70 mL
5 mM	0.39 mL	1.97 mL	3.94 mL
10 mM	0.20 mL	0.99 mL	1.97 mL
50 mM	0.04 mL	0.20 mL	0.39 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for MRT 68921 dihydrochloride

References are publications that support the biological activity of the product.

Petherick Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy. J.Biol.Chem. 2015 PMID: 25833948