NBC 19

Name: NBC 19
Brand: Tocris Bioscience
SKU: 6722

Tocris Bioscience, part of Bio-Techne | Catalog # 6722

Citations (1)

COA / SDS

Potent NLRP3 inflammasome inhibitor

Key Product Details

Description:	Potent NLRP3 inflammasome inhibitor
Chemical Name:	(T4)-[2-Acetyl-4,4,4-trichloro-N-cyclohexyl-3-(imino-κN)butanamidato-κO]diphenylboron
Purity:	≥98% (HPLC)
Molecular Weight:	491.64

View Full Technical Details for NBC 19

Technical Data
Citations

Biological Activity for NBC 19

NBC 19 is a potent NLRP3 inflammasome inhibitor (IC₅₀ = 60-80 nM). Inhibits nigericin- and ATP-induced IL-1β release.

Licensing Information

Sold under license from the University of Manchester.

Technical Data for NBC 19

M. Wt	491.64
Formula	C₂₄H₂₆BCl₃N₂O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2068818-75-5
InChi Key	XLUPBOKHLVUFLX-UHFFFAOYSA-N
Smiles	CC(C1=C(C(Cl)(Cl)Cl)N[B-](C2=CC=CC=C2)(C3=CC=CC=C3)[O+]=C1NC4CCCCC4)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NBC 19

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	49.16	100
	ethanol	49.16	100

Preparing Stock Solutions for NBC 19

The following data is based on the product molecular weight 491.64.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.03 mL	10.17 mL	20.34 mL
5 mM	0.41 mL	2.03 mL	4.07 mL
10 mM	0.20 mL	1.02 mL	2.03 mL
50 mM	0.04 mL	0.20 mL	0.41 mL

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References for NBC 19

References are publications that support the biological activity of the product.

Redondo-Castro Development of a characterised tool kit for the interrogation of NLRP3 inflammasome-dependent responses. Sci.Rep. 2018 PMID: 29618797
Baldwin Boron-Based Inhibitors of the NLRP3 Inflammasome. Cell Chem.Biol. 2017 PMID: 28943355