NBC 19

Name: NBC 19
Brand: Tocris Bioscience
SKU: 6722

Tocris Bioscience, part of Bio-Techne | Catalog # 6722

Citations (1)

COA / SDS

Potent NLRP3 inflammasome inhibitor

Key Product Details

Chemical Name:	(T4)-[2-Acetyl-4,4,4-trichloro-N-cyclohexyl-3-(imino-κN)butanamidato-κO]diphenylboron
Purity:	≥98%

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Technical Data
Citations

Biological Activity for NBC 19

NBC 19 is a potent NLRP3 inflammasome inhibitor (IC₅₀ = 60-80 nM). Inhibits nigericin- and ATP-induced IL-1β release.

Technical Data for NBC 19

Formula	C₂₄H₂₆BCl₃N₂O₂
Storage	Store at -20°C
Purity	≥98%
CAS Number	2068818-75-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NBC 19

Solubility

Soluble Soluble to 100 mM in DMSO and to 100 mM in ethanol

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References for NBC 19

References are publications that support the biological activity of the product.

Baldwin et al. Boron-based inhibitors of the NLRP3 inflammasome. Cell Chem.Biol., 2017;24:1321 PMID: 28943355
Redondo-Castro et al. Development of a characterised tool kit for the interrogation of NLRP3 inflammasome-dependent responses. Sci.Rep., 2018;8:5667 PMID: 29618797

NBC 19

Tocris Bioscience, part of Bio-Techne | Catalog # 6722

Key Product Details

Biological Activity for NBC 19

Technical Data for NBC 19

Solubility for NBC 19

Dilution Calculator

Reconstitution Calculator

References for NBC 19

Product Documents for NBC 19

COA

Certificate of Analysis

SDS

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