NBC 6

Name: NBC 6
Brand: Tocris Bioscience
SKU: 6925

Tocris Bioscience, part of Bio-Techne | Catalog # 6925

(1)

Citations (2)

COA / SDS

NLRP3 inflammasome inhibitor

Key Product Details

Chemical Name:	(T4)-[2-Acetyl-4,4,4-trichloro-3-(imino-κN)butanamidito-κO]diphenylboron
Purity:	≥98%

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Technical Data
Citations / Reviews (1)

Biological Activity for NBC 6

NBC 6 is a NLRP3 inflammasome inhibitor (IC₅₀ = 574 nM). Inhibits nigericin-induced inflammasome activation in THP-1 cells and Imiquimod (Cat. No. 3700) induced IL-1β release from LPS-primed bone marrow-derived macrophages (BMDMs).

Technical Data for NBC 6

Formula	C₁₈H₁₆BCl₃N₂O₂
Storage	Store at -20°C
Purity	≥98%
CAS Number	2068818-02-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NBC 6

Solubility

Soluble Soluble to 100 mM in DMSO and to 5 mM in ethanol

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References for NBC 6

References are publications that support the biological activity of the product.

Baldwin et al. Boron-based inhibitors of the NLRP3 inflammasome. Cell Chem.Biol., 2017;24:1321 PMID: 28943355

NBC 6

Tocris Bioscience, part of Bio-Techne | Catalog # 6925

Key Product Details

Biological Activity for NBC 6

Technical Data for NBC 6

Solubility for NBC 6

Dilution Calculator

Reconstitution Calculator

References for NBC 6

Product Documents for NBC 6

COA

Certificate of Analysis

SDS

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