NBQX

Tocris Bioscience, part of Bio-Techne | Catalog # 0373

(3)

Citations (1551)

COA / SDS

Potent AMPA antagonist; more selective than CNQX (Cat. No. 0190)

Key Product Details

Description:	Potent AMPA antagonist; more selective than CNQX (Cat. No. 0190)
Chemical Name:	2,3-Dioxo-6-nitro-1,2,3,4-tetrahydrobenzo[f]quinoxaline-7-sulfonamide
Purity:	≥98% (HPLC)
Molecular Weight:	336.28

View Full Technical Details for NBQX

Technical Data
Citations / Reviews (3)

Biological Activity for NBQX

NBQX is a selective and competitive AMPA and kainate receptor antagonist (IC₅₀ = 0.15 μM and 4.8 μM, respectively). NBQX blocks the antidepressant effects of 8-Hydroxy-DPAT hydrobromide (Cat. No. 0529), decreases mTOR and BDNF levels. NBQX is neuroprotective, anticonvulsant, antinociceptive and active in vivo.

NBQX disodium salt, a more water-soluble form of NBQX, also available.

Licensing Information

Sold with the permission of Novo Nordisk A/S

Compound Libraries for NBQX

NBQX is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for NBQX

M. Wt	336.28
Formula	C₁₂H₈N₄O₆S
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	118876-58-7
PubChem ID	3272524
InChi Key	UQNAFPHGVPVTAL-UHFFFAOYSA-N
Smiles	NS(=O)(=O)C1=CC=CC2=C3NC(=O)C(=O)NC3=CC(=C12)[N+]([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NBQX

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	33.63	100

Preparing Stock Solutions for NBQX

The following data is based on the product molecular weight 336.28.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.97 mL	14.87 mL	29.74 mL
5 mM	0.59 mL	2.97 mL	5.95 mL
10 mM	0.30 mL	1.49 mL	2.97 mL
50 mM	0.06 mL	0.30 mL	0.59 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for NBQX

References are publications that support the biological activity of the product.

Yoon Antinociceptive interactions between intrathecal gabapentin and MK801 or NBQX in rat formalin test. J.Korean Med.Sci. 2005 PMID: 15832006
Zeman and Lodge Pharmacological characterization of non-NMDA subtypes of glutamate receptors in the neonatal rat hemisected spinal cord in vitro. Br.J.Pharmacol. 1992 PMID: 1382781
Namba Antiepileptogenic and anticonvulsant effects of NBQX, a selective AMPA receptor antagonist, in the rat kindling model of epilepsy. Brain Res. 1994 PMID: 8199874
Sheardown The pharmacology of AMPA receptors and their antagonists. Stroke 1993 PMID: 7504337
Gill The neuroprotective actions of 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxaline (NBQX) in a rat focal ischaemia model. Brain Res. 1992 PMID: 1504814