NDT 30805

Name: NDT 30805
Brand: Tocris Bioscience
SKU: 7808

Tocris Bioscience, part of Bio-Techne | Catalog # 7808

COA / SDS

Potent NLRP3 inflammasome inhibitor

Key Product Details

Description:	Potent NLRP3 inflammasome inhibitor
Chemical Name:	2-((1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)amino)-5-(pyridin-2-ylmethyl)-[1,2,4]triazolo[1,5-a]pyrimidine-7(4H)-thione
Purity:	≥95% (HPLC)
Molecular Weight:	414.53

View Full Technical Details for NDT 30805

Technical Data
Citations

Biological Activity for NDT 30805

NDT 30805 is a potent NLRP3 inflammasome inhibitor. Inhibits IL-1β release in peripheral blood mononuclear cell assay, ASC speck assay and in whole blood (IC₅₀ values are 13 nM, 34 nM and 1500 nM). Inhibits Nigericin (Cat. No. 4312) and ATP-induced IL-1β release. Soluble and uncharged at physiological pH.

Technical Data for NDT 30805

M. Wt	414.53
Formula	C₂₃H₂₂N₆S
Storage	Store at -20°C
Purity	≥95% (HPLC)
PubChem ID	164946940
InChi Key	BHTLYBBOAZYXBF-UHFFFAOYSA-N
Smiles	S=C(C=C(CC1=NC=CC=C1)N2)N(C2=N3)N=C3NC4=C5C(CCC5)=CC6=C4CCC6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NDT 30805

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	41.45	100

Preparing Stock Solutions for NDT 30805

The following data is based on the product molecular weight 414.53.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.41 mL	12.06 mL	24.12 mL
5 mM	0.48 mL	2.41 mL	4.82 mL
10 mM	0.24 mL	1.21 mL	2.41 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

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References for NDT 30805

References are publications that support the biological activity of the product.

Harrison Discovery and optimization of triazolopyrimidinone derivatives as selective NLRP3 inflammasome inhibitors. ACS Med.Chem.Lett. 2022 PMID: 35978696