NIBR LTSi

Name: NIBR LTSi
Brand: Tocris Bioscience
SKU: 8175

Tocris Bioscience, part of Bio-Techne | Catalog # 8175

COA / SDS

Potent and selective LATS inhibitor; activates YAP signaling

Key Product Details

Description:	Potent and selective LATS inhibitor; activates YAP signaling
Chemical Name:	N-[4-[(3R)-Piperidin-3-yl]oxyphenyl]-1H-pyrrolo[2,3-b]pyridin-4-amine
Purity:	≥98% (HPLC)
Molecular Weight:	308.39

View Full Technical Details for NIBR LTSi

Technical Data
Citations

Biological Activity for NIBR LTSi

NIBR-LTSi is a potent and selective large tumor suppressor kinase (LATS) inhibitor (IC₅₀ = 1.4 nM). Also activates YAP signaling (EC₅₀ = 1.0 - 2.7 μM). Promotes liver organoid formation (EC₅₀ = 0.35 μM), hepatocyte proliferation, ISC expansion, and blocks differentiation. NIBR-LTSi is orally bioavailable and suitable for use in vivo and in vitro.

Technical Data for NIBR LTSi

M. Wt	308.39
Formula	C₁₈H₂₀N₄O
Storage	Store at -20°C
Purity	≥98% (HPLC)
PubChem ID	171115368
InChi Key	IYFCFYWXRIVCTH-OAHLLOKOSA-N
Smiles	C1(NC2=CC=C(O[C@H]3CNCCC3)C=C2)=CC=NC4=C1C=CN4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NIBR LTSi

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	30.84	100

Preparing Stock Solutions for NIBR LTSi

The following data is based on the product molecular weight 308.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.24 mL	16.21 mL	32.43 mL
5 mM	0.65 mL	3.24 mL	6.49 mL
10 mM	0.32 mL	1.62 mL	3.24 mL
50 mM	0.06 mL	0.32 mL	0.65 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for NIBR LTSi

References are publications that support the biological activity of the product.

Namoto NIBR-LTSi is a selective LATS kinase inhibitor activating YAP signaling and expanding tissue stem cells in vitro and in vivo. Cell Stem Cell 2024 PMID: 38579685