PD 4'-oxyacetic acid

Name: PD 4'-oxyacetic acid
Brand: Tocris Bioscience
SKU: 7858

Tocris Bioscience, part of Bio-Techne | Catalog # 7858

COA / SDS

Functionalized cereblon ligand for PROTAC development

Key Product Details

Description:	Functionalized cereblon ligand for PROTAC development
Chemical Name:	2-[4-(Tetrahydro-2,4-dioxo-1(2H)-pyrimidinyl)phenoxy]acetic acid
Purity:	≥95% (HPLC)
Molecular Weight:	264.24

View Full Technical Details for PD 4'-oxyacetic acid

Technical Data
Citations

Biological Activity for PD 4'-oxyacetic acid

PD 4'-oxyacetic is a carboxylic acid-functionalized cereblon ligand that can be used for PROTAC^® Degrader development. The compound can be used to develop PD-PROTACs that exhibit improved stability and potency compared with PROTACs synthesized using IMiD (immunomodulatory imide drug) analogs.

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data for PD 4'-oxyacetic acid

M. Wt	264.24
Formula	C₁₂H₁₂N₂O₅
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	2633633-12-0
InChi Key	QZLQKDIAPJHBAU-UHFFFAOYSA-N
Smiles	O=C(COC1=CC=C(N2C(NC(CC2)=O)=O)C=C1)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for PD 4'-oxyacetic acid

References are publications that support the biological activity of the product.

Jarusiewicz Phenyl dihydrouracil: an alternative cereblon binder for PROTAC design. ACS Med.Chem.Lett.