PF 184

Name: PF 184
Brand: Tocris Bioscience
SKU: 4238
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4238

(1)

Citations (4)

COA / SDS

Potent and selective IKKβ inhibitor

Key Product Details

Description:	Potent and selective IKKβ inhibitor
Chemical Name:	8-[[[5-Chloro-2-[3,4-dimethyl-3,4-bis(hydroxymethyl)-1-pyrrolidinyl]-4-pyridinyl]carbonyl]amino]-1-(4-fluorophenyl)-4,5-dihydro-1H-benz[g]indazole-3-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	619.09

View Full Technical Details for PF 184

Technical Data
Citations / Reviews (1)

Biological Activity for PF 184

PF 184 is a potent and selective IKKβ inhibitor (IC₅₀ = 37 nM). Displays selectivity over 85 other kinases. Inhibits IL-1β-induced TNF-α production in a steroid-insensitive in vitro model of oxidative stress.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data for PF 184

M. Wt	619.09
Formula	C₃₂H₃₂ClFN₆O₄
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1187460-81-6
PubChem ID	57519531
InChi Key	JUOWWGNRWRLBSV-MEKGRNQZSA-N
Smiles	FC(C=C4)=CC=C4N(N=C3C(N)=O)C2=C3CCC1=CC=C(NC(C5=CC(N(C6)C[C@@](C)(CO)[C@]6(CO)C)=NC=C5Cl)=O)C=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PF 184

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	61.91	100

Preparing Stock Solutions for PF 184

The following data is based on the product molecular weight 619.09.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.62 mL	8.08 mL	16.15 mL
5 mM	0.32 mL	1.62 mL	3.23 mL
10 mM	0.16 mL	0.81 mL	1.62 mL
50 mM	0.03 mL	0.16 mL	0.32 mL

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References for PF 184

References are publications that support the biological activity of the product.

Sommers Novel tight-binding inhibitory factor-κB kinase (IKK-2) inhibitors demostrate target-specific anti-inflammatory activities in cellular assays and following oral and local delivery in an in vivo model of airway inflammation. J.Pharmacol.Exp.Ther. 2009 PMID: 19478133