PF 4708671

Name: PF 4708671
Brand: Tocris Bioscience
SKU: 4032

Tocris Bioscience, part of Bio-Techne | Catalog # 4032

Citations (42)

COA / SDS

S6K1 inhibitor

Key Product Details

Description:	S6K1 inhibitor
Chemical Name:	2-[[4-(5-Ethylpyrimidin-4-yl)piperazin-1-yl]methyl]-5-(trifluoromethyl)-1H-benzo[d]imidazole
Purity:	≥98% (HPLC)
Molecular Weight:	390.41

View Full Technical Details for PF 4708671

Technical Data
Citations

Biological Activity for PF 4708671

PF 4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) (K_i = 20 nM; IC₅₀ = 160 nM). Suppresses the S6K1-mediated phosphorylation of S6, Rictor and mTOR in response to IGF1; displays no effect on the activity of RSK and MSK in vivo. Exhibits no significant inhibition of S6K2 or other AGC kinases (e.g. Akt, PKA and ROCK) in vitro.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries for PF 4708671

PF 4708671 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for PF 4708671

M. Wt	390.41
Formula	C₁₉H₂₁F₃N₆
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1255517-76-0
PubChem ID	51371303
InChi Key	FBLPQCAQRNSVHB-UHFFFAOYSA-N
Smiles	CCC(C=NC=N2)=C2N1CCN(CC4=NC3=CC(C(F)(F)F)=CC=C3N4)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PF 4708671

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	19.52	50
	ethanol	19.52	50

Preparing Stock Solutions for PF 4708671

The following data is based on the product molecular weight 390.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.12 mL	25.61 mL	51.23 mL
2.5 mM	1.02 mL	5.12 mL	10.25 mL
5 mM	0.51 mL	2.56 mL	5.12 mL
25 mM	0.10 mL	0.51 mL	1.02 mL

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References for PF 4708671

References are publications that support the biological activity of the product.

Pearce Characterisation of PF-4708671 a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1). Biochem.J. 2010 PMID: 20704563