RSK Inhibitors: Small Molecules and Peptides
The 90 kDa ribosomal protein S6 kinases (RSK1-4) are a family of broadly expressed Ser/Thr kinases activated in response to mitogenic stimuli, including growth factors and tumor-promoting phorbol esters. RSKs are directly phosphorylated by ERK1 and ERK2, leading to RSK autophosphorylation and activation. Active RSKs appear to play a major role in transcriptional regulation by translocating to the nucleus and phosphorylating c-Fos and CREB.
3 results for "RSK Inhibitors Small Molecules and Peptides" in Products
3 results for "RSK Inhibitors Small Molecules and Peptides" in Products
RSK Inhibitors: Small Molecules and Peptides
The 90 kDa ribosomal protein S6 kinases (RSK1-4) are a family of broadly expressed Ser/Thr kinases activated in response to mitogenic stimuli, including growth factors and tumor-promoting phorbol esters. RSKs are directly phosphorylated by ERK1 and ERK2, leading to RSK autophosphorylation and activation. Active RSKs appear to play a major role in transcriptional regulation by translocating to the nucleus and phosphorylating c-Fos and CREB.
Selective ribosomal S6 kinase (RSK) inhibitor
| Chemical Name: | 3-[(3,4-Di-O-acetyl-6-deoxy-α-L-mannopyranosyl)oxy]-5,7-dihydro-2-(4-hydroxyphenyl)-4H-1benzopyran-4-one |
| Purity: | ≥95% (HPLC) |
Potent pan-RSK inhibitor
| Chemical Name: | 2,6-Difluoro-4-[4-[4-(4-morpholinyl)phenyl]-3-pyridinyl]phenol |
| Purity: | ≥98% (HPLC) |
S6K1 inhibitor
| Chemical Name: | 2-[[4-(5-Ethylpyrimidin-4-yl)piperazin-1-yl]methyl]-5-(trifluoromethyl)-1H-benzo[d]imidazole |
| Purity: | ≥98% (HPLC) |
