PI 103 hydrochloride

Name: PI 103 hydrochloride
Brand: Tocris Bioscience
SKU: 2930

Tocris Bioscience, part of Bio-Techne | Catalog # 2930

Citations (26)

COA / SDS

Inhibitor of PI 3-kinase, mTOR and DNA-PK

Key Product Details

Description:	Inhibitor of PI 3-kinase, mTOR and DNA-PK
Chemical Name:	3-[4-(4-Morpholinylpyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenol hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	384.82

View Full Technical Details for PI 103 hydrochloride

Technical Data
Citations

Biological Activity for PI 103 hydrochloride

PI 103 hydrochloride is an inhibitor of DNA-PK, PI 3-kinase (p110α) and mTOR (IC₅₀ values are 2, 8, 20, 26, 48, 83, 88, 150, 850, 920, ~ 1000 and 2300 nM for DNA-PK, p110α, mTORC1, PI 3-KC2β, p110δ, mTORC2, p110β, p110γ, ATR, ATM, PI 3-KC2α and hsVPS34 respectively). Inhibits growth of human tumor xenografts in mice in vivo. Induces autophagosome formation in glioma cells.

Compound Libraries for PI 103 hydrochloride

PI 103 hydrochloride is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library, Tocriscreen Antiviral Library and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for PI 103 hydrochloride

M. Wt	384.82
Formula	C₁₉H₁₆N₄O₃.HCl
Storage	Desiccate at +4°C
Purity	≥98% (HPLC)
CAS Number	371935-79-4
PubChem ID	16739368
InChi Key	XSQMYBFFYPTMFE-UHFFFAOYSA-N
Smiles	OC1=CC(C(N=C4N5CCOCC5)=NC3=C4OC2=NC=CC=C23)=CC=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PI 103 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	7.7	20

Preparing Stock Solutions for PI 103 hydrochloride

The following data is based on the product molecular weight 384.82.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	12.99 mL	64.97 mL	129.93 mL
1 mM	2.60 mL	12.99 mL	25.99 mL
2 mM	1.30 mL	6.50 mL	12.99 mL
10 mM	0.26 mL	1.30 mL	2.60 mL

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References for PI 103 hydrochloride

References are publications that support the biological activity of the product.

Fan Akt and autophagy cooperate to promote survival of drug-resistant glioma. Sci.Signal. 2010 PMID: 21062993
Knight A pharmacological map of the PI3-K family defines a role for p110α in Ins signaling. Cell 2006 PMID: 16647110
Raynaud Pharmacologic characterization of a potent inhibitor of class I phosphatidylinositol 3-kinase. Cancer Res. 2007 PMID: 17575152
Fan A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma. Cancer cell 2006 PMID: 16697955