PI 103 hydrochloride

Biological Activity for PI 103 hydrochloride

Technical Data for PI 103 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PI 103 hydrochloride

References for PI 103 hydrochloride

References are publications that support the biological activity of the product.

• Rider C, Shah S, Miller-Larsson A, Giembycz M, Newton R Cytokine-induced loss of glucocorticoid function: effect of kinase inhibitors, long-acting beta(2)-adrenoceptor [corrected] agonist and glucocorticoid receptor ligands. PLoS ONE, 2015;10(1):e0116773. 2015 PMID: 25625944
• Engels M, Rajarajan K, Feistritzer R, Sharma A, Nielsen U, Schalij M, de Vries A, Pijnappels D, Wu S Insulin-like growth factor promotes cardiac lineage induction in vitro by selective expansion of early mesoderm. Stem Cells, 2014;32(6):1493-502. 2014 PMID: 24496962
• Balzarolo M, Karrich J, Engels S, Blom B, Medema J, Wolkers M The transcriptional regulator NAB2 reveals a two-step induction of TRAIL in activated plasmacytoid DCs. Eur J Immunol, 2012;42(11):3019-27. 2012 PMID: 22806638
• Peng F, Yao H, Akturk H, Buch S Platelet-Derived Growth Factor CC-Mediated Neuroprotection against HIV Tat Involves TRPC-Mediated Inactivation of GSK 3beta. PLoS ONE, 2012;7(10):e47572. 2012 PMID: 23077641
• Knight et al. A pharmacological map of the PI3-K family defines a role for p110α in Ins signaling. Cell, 2006;125:733 PMID: 16647110
• Fan et al. A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma. Cancer cell, 2006;9:341 PMID: 16697955
• Raynaud et al. Pharmacologic characterization of a potent inhibitor of class I phosphatidylinositol 3-kinase. Cancer Res., 2007;67:5840 PMID: 17575152
• Fan et al. Akt and autophagy cooperate to promote survival of drug-resistant glioma. Sci.Signal., 2010;3:ra81 PMID: 21062993